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Bromine in PDB 7z76: Crystal Structure of Compound 10 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:ElonginbProtein crystallography data
The structure of Crystal Structure of Compound 10 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb, PDB code: 7z76
was solved by
G.Bader,
J.Boettcher,
B.Wolkerstorfer,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7z76:
The structure of Crystal Structure of Compound 10 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb also contains other interesting chemical elements:
Bromine Binding Sites:
The binding sites of Bromine atom in the Crystal Structure of Compound 10 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb
(pdb code 7z76). This binding sites where shown within
5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Crystal Structure of Compound 10 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb, PDB code: 7z76: Bromine binding site 1 out of 1 in 7z76Go back to Bromine Binding Sites List in 7z76
Bromine binding site 1 out
of 1 in the Crystal Structure of Compound 10 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb
Mono view Stereo pair view
Reference:
C.Kofink,
N.Trainor,
B.Mair,
S.Wohrle,
M.Wurm,
N.Mischerikow,
M.J.Roy,
G.Bader,
P.Greb,
G.Garavel,
E.Diers,
R.Mclennan,
C.Whitworth,
V.Vetma,
K.Rumpel,
M.Scharnweber,
J.E.Fuchs,
T.Gerstberger,
Y.Cui,
G.Gremel,
P.Chetta,
S.Hopf,
N.Budano,
J.Rinnenthal,
G.Gmaschitz,
M.Mayer,
M.Koegl,
A.Ciulli,
H.Weinstabl,
W.Farnaby.
A Selective and Orally Bioavailable Vhl-Recruiting Protac Achieves SMARCA2 Degradation in Vivo. Nat Commun V. 13 5969 2022.
Page generated: Tue Apr 4 17:43:45 2023
ISSN: ESSN 2041-1723 PubMed: 36216795 DOI: 10.1038/S41467-022-33430-6 |
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