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Bromine in PDB 8e9e: Rat Protein Farnesyltransferase in Complex with Fpp and Inhibitor 2FEnzymatic activity of Rat Protein Farnesyltransferase in Complex with Fpp and Inhibitor 2F
All present enzymatic activity of Rat Protein Farnesyltransferase in Complex with Fpp and Inhibitor 2F:
2.5.1.58; 2.5.1.59; Protein crystallography data
The structure of Rat Protein Farnesyltransferase in Complex with Fpp and Inhibitor 2F, PDB code: 8e9e
was solved by
Y.Wang,
Y.Shi,
L.S.Beese,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 8e9e:
The structure of Rat Protein Farnesyltransferase in Complex with Fpp and Inhibitor 2F also contains other interesting chemical elements:
Bromine Binding Sites:
The binding sites of Bromine atom in the Rat Protein Farnesyltransferase in Complex with Fpp and Inhibitor 2F
(pdb code 8e9e). This binding sites where shown within
5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Rat Protein Farnesyltransferase in Complex with Fpp and Inhibitor 2F, PDB code: 8e9e: Bromine binding site 1 out of 1 in 8e9eGo back to Bromine Binding Sites List in 8e9e
Bromine binding site 1 out
of 1 in the Rat Protein Farnesyltransferase in Complex with Fpp and Inhibitor 2F
Mono view Stereo pair view
Reference:
Y.Wang,
F.Xu,
C.B.Nichols,
Y.Shi,
H.W.Hellinga,
J.A.Alspaugh,
M.D.Distefano,
L.S.Beese.
Structure-Guided Discovery of Potent Antifungals That Prevent Ras Signaling By Inhibiting Protein Farnesyltransferase. J.Med.Chem. V. 65 13753 2022.
Page generated: Tue Apr 4 17:46:16 2023
ISSN: ISSN 0022-2623 PubMed: 36218371 DOI: 10.1021/ACS.JMEDCHEM.2C00902 |
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