Atomistry » Bromine » PDB 8d90-8gb1 » 8g6t
Atomistry »
  Bromine »
    PDB 8d90-8gb1 »
      8g6t »

Bromine in PDB 8g6t: Bromodomain of Cbp Liganded with Inhibitor ICBP2

Enzymatic activity of Bromodomain of Cbp Liganded with Inhibitor ICBP2

All present enzymatic activity of Bromodomain of Cbp Liganded with Inhibitor ICBP2:
2.3.1.48;

Protein crystallography data

The structure of Bromodomain of Cbp Liganded with Inhibitor ICBP2, PDB code: 8g6t was solved by E.Schonbrunn, M.Bikowitz, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 33.65 / 1.75
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 34.58, 55.91, 69.67, 93.06, 103.16, 106.53
R / Rfree (%) 19 / 22.2

Other elements in 8g6t:

The structure of Bromodomain of Cbp Liganded with Inhibitor ICBP2 also contains other interesting chemical elements:

Nickel (Ni) 2 atoms

Bromine Binding Sites:

The binding sites of Bromine atom in the Bromodomain of Cbp Liganded with Inhibitor ICBP2 (pdb code 8g6t). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total 8 binding sites of Bromine where determined in the Bromodomain of Cbp Liganded with Inhibitor ICBP2, PDB code: 8g6t:
Jump to Bromine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Bromine binding site 1 out of 8 in 8g6t

Go back to Bromine Binding Sites List in 8g6t
Bromine binding site 1 out of 8 in the Bromodomain of Cbp Liganded with Inhibitor ICBP2


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Bromodomain of Cbp Liganded with Inhibitor ICBP2 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Br1201

b:38.1
occ:1.00
 BR37 A:YRI1201 0.0 38.1 1.0
C36 A:YRI1201 1.9 26.3 1.0
C38 A:YRI1201 2.8 26.8 1.0
C35 A:YRI1201 2.9 24.4 1.0
BR39 A:YRI1201 3.3 52.1 1.0
CE2 A:PHE1177 3.6 21.1 1.0
CB A:ARG1173 3.6 21.9 1.0
CD2 A:PHE1177 3.7 22.1 1.0
CG2 A:VAL1174 3.8 15.1 1.0
CG A:PRO1110 3.8 20.1 1.0
NH1 A:ARG1173 3.9 31.9 1.0
CZ A:ARG1173 3.9 28.1 1.0
N A:VAL1174 4.1 16.1 1.0
C32 A:YRI1201 4.1 29.3 1.0
NE A:ARG1173 4.2 24.4 1.0
C34 A:YRI1201 4.2 29.6 1.0
C A:ARG1173 4.3 15.4 1.0
NH2 A:ARG1173 4.4 35.1 1.0
CD A:ARG1173 4.4 24.0 1.0
CA A:VAL1174 4.4 14.2 1.0
CA A:ARG1173 4.6 15.8 1.0
CZ A:PHE1177 4.6 22.2 1.0
C33 A:YRI1201 4.7 27.3 1.0
CG A:ARG1173 4.7 19.4 1.0
O A:ARG1173 4.7 16.3 1.0
CD A:PRO1110 4.8 16.6 1.0
CB A:VAL1174 4.8 14.5 1.0
CG A:PHE1177 4.8 16.8 1.0
CB A:PRO1110 5.0 19.1 1.0

Bromine binding site 2 out of 8 in 8g6t

Go back to Bromine Binding Sites List in 8g6t
Bromine binding site 2 out of 8 in the Bromodomain of Cbp Liganded with Inhibitor ICBP2


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 2 of Bromodomain of Cbp Liganded with Inhibitor ICBP2 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Br1201

b:52.1
occ:1.00
 BR39 A:YRI1201 0.0 52.1 1.0
C35 A:YRI1201 1.9 24.4 1.0
C36 A:YRI1201 2.9 26.3 1.0
C34 A:YRI1201 2.9 29.6 1.0
O A:PRO1106 3.3 19.2 1.0
BR37 A:YRI1201 3.3 38.1 1.0
CE2 A:PHE1177 3.6 21.1 1.0
CD A:PRO1110 3.6 16.6 1.0
CB A:PRO1106 3.8 25.9 1.0
CG A:PRO1110 3.8 20.1 1.0
CB A:LEU1109 3.9 19.3 1.0
CD2 A:PHE1177 3.9 22.1 1.0
C A:PRO1106 4.1 20.8 1.0
C33 A:YRI1201 4.2 27.3 1.0
C38 A:YRI1201 4.2 26.8 1.0
CG A:LEU1109 4.5 21.8 1.0
CA A:PRO1106 4.6 23.0 1.0
N A:PRO1110 4.6 13.4 1.0
CD1 A:LEU1109 4.6 33.8 1.0
C32 A:YRI1201 4.7 29.3 1.0
CG A:PRO1106 4.7 29.8 1.0
CZ A:PHE1177 4.8 22.2 1.0
CA A:LEU1109 4.8 18.6 1.0
N A:LEU1109 4.9 18.6 1.0

Bromine binding site 3 out of 8 in 8g6t

Go back to Bromine Binding Sites List in 8g6t
Bromine binding site 3 out of 8 in the Bromodomain of Cbp Liganded with Inhibitor ICBP2


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 3 of Bromodomain of Cbp Liganded with Inhibitor ICBP2 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Br1201

b:38.2
occ:1.00
 BR37 B:YRI1201 0.0 38.2 1.0
C36 B:YRI1201 1.9 26.2 1.0
C38 B:YRI1201 2.8 23.0 1.0
C35 B:YRI1201 2.9 28.7 1.0
BR39 B:YRI1201 3.4 56.5 1.0
CE2 B:PHE1177 3.6 25.2 1.0
CB B:ARG1173 3.7 13.1 1.0
CD2 B:PHE1177 3.7 19.2 1.0
CG B:PRO1110 3.9 22.5 1.0
CG2 B:VAL1174 3.9 14.6 1.0
NH1 B:ARG1173 3.9 27.6 1.0
CZ B:ARG1173 3.9 22.7 1.0
C32 B:YRI1201 4.1 27.9 1.0
NE B:ARG1173 4.1 22.2 1.0
N B:VAL1174 4.2 13.6 1.0
C34 B:YRI1201 4.2 28.0 1.0
CD B:ARG1173 4.3 19.0 1.0
C B:ARG1173 4.4 13.4 1.0
NH2 B:ARG1173 4.4 24.7 1.0
CA B:VAL1174 4.5 12.3 1.0
O D:HOH1311 4.6 17.0 1.0
CZ B:PHE1177 4.6 20.7 1.0
C33 B:YRI1201 4.7 28.8 1.0
CG B:ARG1173 4.7 16.6 1.0
CA B:ARG1173 4.7 13.2 1.0
O B:ARG1173 4.8 15.0 1.0
CD B:PRO1110 4.8 18.9 1.0
CB B:VAL1174 4.8 13.8 1.0
CG B:PHE1177 4.9 18.3 1.0
CB B:PRO1110 4.9 18.1 1.0

Bromine binding site 4 out of 8 in 8g6t

Go back to Bromine Binding Sites List in 8g6t
Bromine binding site 4 out of 8 in the Bromodomain of Cbp Liganded with Inhibitor ICBP2


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 4 of Bromodomain of Cbp Liganded with Inhibitor ICBP2 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Br1201

b:56.5
occ:1.00
 BR39 B:YRI1201 0.0 56.5 1.0
C35 B:YRI1201 1.9 28.7 1.0
C34 B:YRI1201 2.9 28.0 1.0
C36 B:YRI1201 2.9 26.2 1.0
O B:PRO1106 3.4 24.0 1.0
CE2 B:PHE1177 3.4 25.2 1.0
BR37 B:YRI1201 3.4 38.2 1.0
CD B:PRO1110 3.7 18.9 1.0
CD2 B:PHE1177 3.9 19.2 1.0
CG B:PRO1110 3.9 22.5 1.0
CB B:PRO1106 4.0 32.4 1.0
CD1 B:LEU1109 4.0 25.5 1.0
CB B:LEU1109 4.1 27.5 1.0
C33 B:YRI1201 4.2 28.8 1.0
C38 B:YRI1201 4.2 23.0 1.0
CG B:LEU1109 4.3 27.5 1.0
C B:PRO1106 4.3 28.5 1.0
O D:HOH1386 4.5 29.4 1.0
CZ B:PHE1177 4.6 20.7 1.0
O D:HOH1371 4.6 27.2 1.0
N B:PRO1110 4.6 17.1 1.0
C32 B:YRI1201 4.7 27.9 1.0
CG B:PRO1106 4.7 30.0 1.0
CA B:PRO1106 4.7 35.0 1.0
CA B:LEU1109 4.9 23.5 1.0
N B:LEU1109 4.9 19.4 1.0

Bromine binding site 5 out of 8 in 8g6t

Go back to Bromine Binding Sites List in 8g6t
Bromine binding site 5 out of 8 in the Bromodomain of Cbp Liganded with Inhibitor ICBP2


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 5 of Bromodomain of Cbp Liganded with Inhibitor ICBP2 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Br1201

b:43.6
occ:1.00
 BR37 C:YRI1201 0.0 43.6 1.0
C36 C:YRI1201 1.9 40.6 1.0
C38 C:YRI1201 2.9 39.9 1.0
C35 C:YRI1201 2.9 48.5 1.0
BR39 C:YRI1201 3.3 91.0 1.0
CB C:ARG1173 3.6 19.2 1.0
CE2 C:PHE1177 3.8 26.3 1.0
CG2 C:VAL1174 3.8 22.0 1.0
CG C:PRO1110 3.8 26.0 1.0
CZ C:ARG1173 3.9 28.4 1.0
CD2 C:PHE1177 3.9 25.5 1.0
NE C:ARG1173 4.0 24.8 1.0
NH1 C:ARG1173 4.0 34.5 1.0
N C:VAL1174 4.1 16.6 1.0
C32 C:YRI1201 4.1 45.3 1.0
C34 C:YRI1201 4.2 44.3 1.0
NH2 C:ARG1173 4.3 34.8 1.0
O C:HOH1354 4.3 18.7 1.0
C C:ARG1173 4.4 19.0 1.0
CD C:ARG1173 4.4 22.6 1.0
CA C:VAL1174 4.5 15.8 1.0
CA C:ARG1173 4.6 18.1 1.0
CG C:ARG1173 4.7 22.0 1.0
C33 C:YRI1201 4.7 48.0 1.0
CZ C:PHE1177 4.8 24.4 1.0
CB C:VAL1174 4.8 21.8 1.0
CD C:PRO1110 4.8 24.0 1.0
O C:ARG1173 4.8 18.1 1.0
CB C:PRO1110 4.9 24.0 1.0

Bromine binding site 6 out of 8 in 8g6t

Go back to Bromine Binding Sites List in 8g6t
Bromine binding site 6 out of 8 in the Bromodomain of Cbp Liganded with Inhibitor ICBP2


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 6 of Bromodomain of Cbp Liganded with Inhibitor ICBP2 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Br1201

b:91.0
occ:1.00
 BR39 C:YRI1201 0.0 91.0 1.0
C35 C:YRI1201 1.9 48.5 1.0
C36 C:YRI1201 2.9 40.6 1.0
C34 C:YRI1201 2.9 44.3 1.0
BR37 C:YRI1201 3.3 43.6 1.0
CE2 C:PHE1177 3.7 26.3 1.0
CD C:PRO1110 3.8 24.0 1.0
CG C:PRO1110 3.8 26.0 1.0
O C:PRO1106 3.8 31.4 1.0
CB C:LEU1109 4.0 29.7 1.0
CD2 C:PHE1177 4.2 25.5 1.0
C33 C:YRI1201 4.2 48.0 1.0
C38 C:YRI1201 4.2 39.9 1.0
CB C:PRO1106 4.3 40.3 1.0
N C:PRO1110 4.6 20.4 1.0
C32 C:YRI1201 4.7 45.3 1.0
C C:PRO1106 4.7 35.0 1.0
CZ C:PHE1177 4.8 24.4 1.0
CG C:LEU1109 4.8 36.2 1.0
NH1 C:ARG1173 5.0 34.5 1.0

Bromine binding site 7 out of 8 in 8g6t

Go back to Bromine Binding Sites List in 8g6t
Bromine binding site 7 out of 8 in the Bromodomain of Cbp Liganded with Inhibitor ICBP2


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 7 of Bromodomain of Cbp Liganded with Inhibitor ICBP2 within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Br1201

b:39.4
occ:1.00
 BR37 D:YRI1201 0.0 39.4 1.0
C36 D:YRI1201 1.9 25.9 1.0
C38 D:YRI1201 2.8 26.6 1.0
C35 D:YRI1201 2.9 36.7 1.0
BR39 D:YRI1201 3.4 68.2 1.0
CE2 D:PHE1177 3.6 23.2 1.0
CB D:ARG1173 3.6 18.7 1.0
CD2 D:PHE1177 3.7 24.8 1.0
CG D:PRO1110 3.7 21.5 1.0
CG2 D:VAL1174 3.9 18.8 1.0
CZ D:ARG1173 4.0 25.2 1.0
NH1 D:ARG1173 4.0 25.3 1.0
C32 D:YRI1201 4.1 30.0 1.0
N D:VAL1174 4.1 14.5 1.0
NE D:ARG1173 4.1 23.9 1.0
C34 D:YRI1201 4.2 30.6 1.0
C D:ARG1173 4.2 14.4 1.0
CD D:ARG1173 4.3 19.8 1.0
CA D:VAL1174 4.4 14.2 1.0
NH2 D:ARG1173 4.5 30.8 1.0
CA D:ARG1173 4.6 14.7 1.0
O D:ARG1173 4.6 15.9 1.0
O D:HOH1368 4.6 17.1 1.0
CZ D:PHE1177 4.6 24.4 1.0
CG D:ARG1173 4.6 17.2 1.0
C33 D:YRI1201 4.7 30.1 1.0
CD D:PRO1110 4.7 16.2 1.0
CB D:VAL1174 4.8 16.4 1.0
CG D:PHE1177 4.8 18.1 1.0
CB D:PRO1110 4.9 17.4 1.0

Bromine binding site 8 out of 8 in 8g6t

Go back to Bromine Binding Sites List in 8g6t
Bromine binding site 8 out of 8 in the Bromodomain of Cbp Liganded with Inhibitor ICBP2


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 8 of Bromodomain of Cbp Liganded with Inhibitor ICBP2 within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Br1201

b:68.2
occ:1.00
 BR39 D:YRI1201 0.0 68.2 1.0
C35 D:YRI1201 1.9 36.7 1.0
C34 D:YRI1201 2.9 30.6 1.0
C36 D:YRI1201 2.9 25.9 1.0
O D:PRO1106 3.4 17.3 1.0
BR37 D:YRI1201 3.4 39.4 1.0
CE2 D:PHE1177 3.5 23.2 1.0
CD D:PRO1110 3.8 16.2 1.0
CG D:PRO1110 3.9 21.5 1.0
CD2 D:PHE1177 3.9 24.8 1.0
CB D:LEU1109 4.0 22.7 1.0
CB D:PRO1106 4.0 24.6 1.0
C33 D:YRI1201 4.2 30.1 1.0
C38 D:YRI1201 4.2 26.6 1.0
C D:PRO1106 4.3 17.6 1.0
CD1 D:LEU1109 4.3 30.4 1.0
CG D:LEU1109 4.6 24.5 1.0
C32 D:YRI1201 4.7 30.0 1.0
N D:PRO1110 4.7 16.0 1.0
CZ D:PHE1177 4.7 24.4 1.0
CG D:PRO1106 4.7 26.5 1.0
CA D:PRO1106 4.8 20.3 1.0
CA D:LEU1109 4.9 17.3 1.0

Reference:

E.Schonbrunn, M.Bikowitz. Group 3 Medulloblastoma Transcriptional Networks Are Sensitive to EP300/Cbp Bromodomain Inhibition To Be Published.
Page generated: Mon Jul 7 12:17:15 2025

Last articles

Ca in 5MHL
Ca in 5MHC
Ca in 5MFL
Ca in 5MFN
Ca in 5MFH
Ca in 5MFE
Ca in 5MFG
Ca in 5MFA
Ca in 5MF4
Ca in 5MEY
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy