Bromine in PDB 8jfx: Trub Domain of TRUB1

All present enzymatic activity of Trub Domain of TRUB1:
5.4.99.25;

The structure of Trub Domain of TRUB1, PDB code: 8jfx was solved by Y.M.Xuan, Q.G.Gong, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	26.74 / 2.20
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	50.315, 53.487, 90.134, 90, 90, 90
R / Rfree (%)	20.5 / 24.2

The binding sites of Bromine atom in the Trub Domain of TRUB1 (pdb code 8jfx). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total 2 binding sites of Bromine where determined in the Trub Domain of TRUB1, PDB code: 8jfx:
Jump to Bromine binding site number: 1; 2;

Bromine binding site 1 out of 2 in the Trub Domain of TRUB1


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Trub Domain of TRUB1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Br401 b:80.5 occ:1.00 N A:THR229 3.3 56.5 1.0 CA A:GLY250 3.5 45.1 1.0 CA A:VAL228 3.8 70.4 1.0 C A:GLY250 3.8 65.3 1.0 N A:GLY252 3.9 66.4 1.0 N A:GLY251 3.9 69.7 1.0 C A:VAL228 4.0 68.8 1.0 CB A:VAL228 4.0 68.2 1.0 N A:GLY250 4.1 49.9 1.0 CB A:THR229 4.1 54.1 1.0 CA A:THR229 4.2 54.0 1.0 O A:THR229 4.3 45.4 1.0 N A:PHE253 4.3 65.1 1.0 CG1 A:VAL228 4.3 67.3 1.0 OG1 A:THR229 4.4 60.6 1.0 O A:GLY250 4.4 54.2 1.0 CA A:GLY252 4.5 72.5 1.0 C A:GLY252 4.5 68.8 1.0 C A:THR229 4.7 53.5 1.0 C A:GLY251 4.8 75.0 1.0 O A:PRO227 4.8 80.9 1.0 CB A:PHE253 4.9 57.4 1.0 CA A:GLY251 4.9 77.5 1.0 CA A:PHE253 5.0 59.8 1.0

Bromine binding site 2 out of 2 in the Trub Domain of TRUB1


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 2 of Trub Domain of TRUB1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Br402 b:73.5 occ:1.00 N A:ARG256 3.3 50.8 1.0 N A:ILE255 3.5 48.3 1.0 CD A:ARG256 3.5 56.4 1.0 CG A:ARG256 3.6 60.6 1.0 CB A:ARG256 3.6 52.5 1.0 NH1 A:ARG256 3.7 54.4 1.0 CA A:TYR254 3.8 58.5 1.0 CB A:TYR254 3.9 60.2 1.0 C A:TYR254 3.9 54.6 1.0 CA A:ARG256 4.1 45.8 1.0 C A:ILE255 4.3 50.2 1.0 CA A:ILE255 4.3 52.0 1.0 CD1 A:TYR254 4.3 67.1 1.0 CG A:PRO198 4.5 71.3 1.0 NE A:ARG256 4.5 61.9 1.0 CZ A:ARG256 4.6 65.0 1.0 CG A:TYR254 4.6 67.3 1.0 CB A:ILE255 4.7 51.8 1.0 O A:HOH545 4.7 61.8 1.0 O A:TYR254 4.9 53.1 1.0 N A:SER257 5.0 51.9 1.0

Y.M.Xuan, Q.G.Gong. Structural Basis of Pri-Let-7 Recognition By Human Pseudouridine Synthase TRUB1 To Be Published.