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PDB 8kh6-8r41 »
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Bromine in PDB 8qcd: Structure of Protein Kinase CK2 Catalytic Subunit (Isoform CK2ALPHA'; CSNK2A2 Gene Product) in Complex with the Inhibitor 4,5,6,7- Tetrabromobenzotriazole
Enzymatic activity of Structure of Protein Kinase CK2 Catalytic Subunit (Isoform CK2ALPHA'; CSNK2A2 Gene Product) in Complex with the Inhibitor 4,5,6,7- Tetrabromobenzotriazole
All present enzymatic activity of Structure of Protein Kinase CK2 Catalytic Subunit (Isoform CK2ALPHA'; CSNK2A2 Gene Product) in Complex with the Inhibitor 4,5,6,7- Tetrabromobenzotriazole:
2.7.11.1;
2.7.11.1;
Protein crystallography data
The structure of Structure of Protein Kinase CK2 Catalytic Subunit (Isoform CK2ALPHA'; CSNK2A2 Gene Product) in Complex with the Inhibitor 4,5,6,7- Tetrabromobenzotriazole, PDB code: 8qcd
was solved by
C.Werner,
K.Niefind,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 24.92 / 1.03 |
| Space group | P 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 46.338, 47.701, 50.342, 113.48, 90.45, 90.17 |
| R / Rfree (%) | 14.4 / 15.6 |
Bromine Binding Sites:
The binding sites of Bromine atom in the Structure of Protein Kinase CK2 Catalytic Subunit (Isoform CK2ALPHA'; CSNK2A2 Gene Product) in Complex with the Inhibitor 4,5,6,7- Tetrabromobenzotriazole
(pdb code 8qcd). This binding sites where shown within
5.0 Angstroms radius around Bromine atom.
In total 4 binding sites of Bromine where determined in the Structure of Protein Kinase CK2 Catalytic Subunit (Isoform CK2ALPHA'; CSNK2A2 Gene Product) in Complex with the Inhibitor 4,5,6,7- Tetrabromobenzotriazole, PDB code: 8qcd:
Jump to Bromine binding site number: 1; 2; 3; 4;
In total 4 binding sites of Bromine where determined in the Structure of Protein Kinase CK2 Catalytic Subunit (Isoform CK2ALPHA'; CSNK2A2 Gene Product) in Complex with the Inhibitor 4,5,6,7- Tetrabromobenzotriazole, PDB code: 8qcd:
Jump to Bromine binding site number: 1; 2; 3; 4;
Bromine binding site 1 out of 4 in 8qcd
Go back to
Bromine Binding Sites List in 8qcd
Bromine binding site 1 out
of 4 in the Structure of Protein Kinase CK2 Catalytic Subunit (Isoform CK2ALPHA'; CSNK2A2 Gene Product) in Complex with the Inhibitor 4,5,6,7- Tetrabromobenzotriazole
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 1 of Structure of Protein Kinase CK2 Catalytic Subunit (Isoform CK2ALPHA'; CSNK2A2 Gene Product) in Complex with the Inhibitor 4,5,6,7- Tetrabromobenzotriazole within 5.0Å range:
|
Bromine binding site 2 out of 4 in 8qcd
Go back to
Bromine Binding Sites List in 8qcd
Bromine binding site 2 out
of 4 in the Structure of Protein Kinase CK2 Catalytic Subunit (Isoform CK2ALPHA'; CSNK2A2 Gene Product) in Complex with the Inhibitor 4,5,6,7- Tetrabromobenzotriazole
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 2 of Structure of Protein Kinase CK2 Catalytic Subunit (Isoform CK2ALPHA'; CSNK2A2 Gene Product) in Complex with the Inhibitor 4,5,6,7- Tetrabromobenzotriazole within 5.0Å range:
|
Bromine binding site 3 out of 4 in 8qcd
Go back to
Bromine Binding Sites List in 8qcd
Bromine binding site 3 out
of 4 in the Structure of Protein Kinase CK2 Catalytic Subunit (Isoform CK2ALPHA'; CSNK2A2 Gene Product) in Complex with the Inhibitor 4,5,6,7- Tetrabromobenzotriazole
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 3 of Structure of Protein Kinase CK2 Catalytic Subunit (Isoform CK2ALPHA'; CSNK2A2 Gene Product) in Complex with the Inhibitor 4,5,6,7- Tetrabromobenzotriazole within 5.0Å range:
|
Bromine binding site 4 out of 4 in 8qcd
Go back to
Bromine Binding Sites List in 8qcd
Bromine binding site 4 out
of 4 in the Structure of Protein Kinase CK2 Catalytic Subunit (Isoform CK2ALPHA'; CSNK2A2 Gene Product) in Complex with the Inhibitor 4,5,6,7- Tetrabromobenzotriazole
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 4 of Structure of Protein Kinase CK2 Catalytic Subunit (Isoform CK2ALPHA'; CSNK2A2 Gene Product) in Complex with the Inhibitor 4,5,6,7- Tetrabromobenzotriazole within 5.0Å range:
|
Reference:
C.Werner,
D.Lindenblatt,
K.Viht,
A.Uri,
K.Niefind.
Discovery and Exploration of Protein Kinase CK2 Binding Sites Using CK2ALPHA CYS336SER As An Exquisite Crystallographic Tool Kinases Phosphatases 2023.
DOI: 10.3390/KINASESPHOSPHATASES1040018
Page generated: Thu Jul 11 05:30:01 2024
DOI: 10.3390/KINASESPHOSPHATASES1040018
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