Bromine in PDB 9hmm: Crystal Structure of Mouse ADAT2/ADAT3 Trna Deamination Complex A180V Mutant

All present enzymatic activity of Crystal Structure of Mouse ADAT2/ADAT3 Trna Deamination Complex A180V Mutant:
3.5.4.33;

The structure of Crystal Structure of Mouse ADAT2/ADAT3 Trna Deamination Complex A180V Mutant, PDB code: 9hmm was solved by H.R.Vaca, C.Romier, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.19 / 2.90
Space group	P 2 21 21
Cell size a, b, c (Å), α, β, γ (°)	51.903, 106.398, 129.199, 90, 90, 90
R / Rfree (%)	19.5 / 24.5

The structure of Crystal Structure of Mouse ADAT2/ADAT3 Trna Deamination Complex A180V Mutant also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Bromine atom in the Crystal Structure of Mouse ADAT2/ADAT3 Trna Deamination Complex A180V Mutant (pdb code 9hmm). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total 2 binding sites of Bromine where determined in the Crystal Structure of Mouse ADAT2/ADAT3 Trna Deamination Complex A180V Mutant, PDB code: 9hmm:
Jump to Bromine binding site number: 1; 2;

Bromine binding site 1 out of 2 in the Crystal Structure of Mouse ADAT2/ADAT3 Trna Deamination Complex A180V Mutant


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Crystal Structure of Mouse ADAT2/ADAT3 Trna Deamination Complex A180V Mutant within 5.0Å range: probe atom residue distance (Å) B Occ B:Br402 b:95.5 occ:1.00 NH1 B:ARG292 3.3 78.4 1.0 N B:ARG288 3.3 77.5 1.0 CD B:ARG292 3.7 78.0 1.0 CG B:ARG292 3.9 86.4 1.0 C B:ARG288 3.9 76.0 1.0 CB B:PHE287 4.0 74.0 1.0 CA B:ARG288 4.1 77.1 1.0 CA B:PHE287 4.1 72.5 1.0 O B:ARG288 4.1 78.9 1.0 N B:VAL289 4.2 70.9 1.0 C B:PHE287 4.2 74.9 1.0 CZ B:ARG292 4.3 81.6 1.0 NE B:ARG292 4.4 87.4 1.0 CG1 B:VAL289 4.5 66.9 1.0 CD2 A:LEU138 4.5 73.3 1.0 CD1 B:PHE287 4.5 74.8 1.0 CB B:ARG288 4.6 77.4 1.0 CD1 A:LEU138 4.6 66.0 1.0 CA B:VAL289 4.6 74.9 1.0 CG B:PHE287 4.8 75.5 1.0

Bromine binding site 2 out of 2 in the Crystal Structure of Mouse ADAT2/ADAT3 Trna Deamination Complex A180V Mutant


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 2 of Crystal Structure of Mouse ADAT2/ADAT3 Trna Deamination Complex A180V Mutant within 5.0Å range: probe atom residue distance (Å) B Occ B:Br403 b:132.5 occ:1.00 NH1 B:ARG170 3.5 116.3 1.0 N B:ALA28 3.5 102.4 1.0 CB B:ALA28 3.9 99.4 1.0 CD B:ARG170 4.0 116.5 1.0 N B:PHE165 4.0 115.9 1.0 CD1 B:PHE165 4.0 115.0 1.0 CB B:PHE165 4.1 121.0 1.0 CB B:LEU164 4.2 124.3 1.0 CG B:ARG170 4.2 117.1 1.0 CA B:ALA28 4.3 99.5 1.0 CA B:GLN27 4.3 110.4 1.0 CZ3 B:TRP26 4.4 114.3 1.0 C B:GLN27 4.4 106.6 1.0 CG B:GLN27 4.5 118.4 1.0 CZ B:ARG170 4.5 118.5 1.0 CG B:PHE165 4.5 118.2 1.0 CA B:PHE165 4.6 121.5 1.0 O B:ALA28 4.6 109.5 1.0 NE B:ARG170 4.7 121.3 1.0 O B:PHE165 4.8 125.9 1.0 CB B:GLN27 4.8 113.2 1.0 CD1 B:LEU164 4.8 121.3 1.0 CE3 B:TRP26 5.0 112.8 1.0 C B:ALA28 5.0 100.4 1.0

J.Del-Pozo-Rodriguez, P.Tilly, R.Lecat, H.R.Vaca, L.Mosser, E.Brivio, T.Balla, M.V.Gomes, E.Ramos-Morales, N.Schwaller, T.Salinas-Giege, G.Vannoy, E.M.England, A.Kern Lovgren, M.O'leary, M.Chopra, N.M.Ojeda, M.B.Toosi, A.Eslahi, M.Alerasool, M.Mojarrad, L.S.Pais, R.C.Yeh, D.L.Gable, M.O.Hashem, F.Abdulwahab, M.Rakiz Alqurashi, L.Z.Sbeih, O.A.Adas Blanco, R.A.Khater, G.Oprea, A.Rad, H.Alzaidan, H.Aldhalaan, E.Tous, A.Alsagheir, M.Alowain, A.Tamim, K.Alfayez, A.Alhashem, A.Alnuzha, M.Kamel, B.S.Al-Awam, W.Elnaggar, N.Almenabawy, A.O'donnell-Luria, J.E.Neil, J.G.Gleeson, C.A.Walsh, F.S.Alkuraya, L.Alabdi, N.Elkhateeb, L.Selim, S.Srivastava, D.D.Nedialkova, L.Drouard, C.Romier, E.Bayam, J.D.Godin. ADAT3 Variants Disrupt the Activity of the Adat Trna Deaminase Complex and Impair Neuronal Migration. Brain 2025.
ISSN: ISSN 1460-2156
PubMed: 40120092
DOI: 10.1093/BRAIN/AWAF109