Bromine in PDB 9iir: Human Alpha 7 Nicotinic Acetylcholine Receptor in Complex with GAT107 and Calcium (Desensitized State)

The structure of Human Alpha 7 Nicotinic Acetylcholine Receptor in Complex with GAT107 and Calcium (Desensitized State) also contains other interesting chemical elements:

Calcium

(Ca)

5 atoms

The binding sites of Bromine atom in the Human Alpha 7 Nicotinic Acetylcholine Receptor in Complex with GAT107 and Calcium (Desensitized State) (pdb code 9iir). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total 5 binding sites of Bromine where determined in the Human Alpha 7 Nicotinic Acetylcholine Receptor in Complex with GAT107 and Calcium (Desensitized State), PDB code: 9iir:
Jump to Bromine binding site number: 1; 2; 3; 4; 5;

Bromine binding site 1 out of 5 in the Human Alpha 7 Nicotinic Acetylcholine Receptor in Complex with GAT107 and Calcium (Desensitized State)


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Human Alpha 7 Nicotinic Acetylcholine Receptor in Complex with GAT107 and Calcium (Desensitized State) within 5.0Å range: probe atom residue distance (Å) B Occ A:Br601 b:161.3 occ:1.00 BR24 A:YLI601 0.0 161.3 1.0 C21 A:YLI601 1.9 130.0 1.0 C20 A:YLI601 2.9 127.5 1.0 C22 A:YLI601 2.9 128.3 1.0 CD2 A:LEU269 3.7 111.6 1.0 CA A:GLY305 3.8 83.2 1.0 CD1 B:LEU247 3.9 99.2 1.0 CD2 B:LEU247 4.1 98.8 1.0 C19 A:YLI601 4.2 125.7 1.0 C23 A:YLI601 4.2 126.1 1.0 O A:MET301 4.4 106.4 1.0 CB B:LEU243 4.4 87.8 1.0 CG B:LEU247 4.4 95.3 1.0 N A:GLY305 4.4 90.8 1.0 O B:LEU243 4.5 102.6 1.0 CB B:LEU247 4.6 92.6 1.0 CD1 A:LEU269 4.7 110.6 1.0 C18 A:YLI601 4.8 124.5 1.0 C B:LEU243 4.8 91.9 1.0 CG A:LEU269 4.8 113.1 1.0 C A:GLY305 4.9 85.9 1.0

Bromine binding site 2 out of 5 in the Human Alpha 7 Nicotinic Acetylcholine Receptor in Complex with GAT107 and Calcium (Desensitized State)


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 2 of Human Alpha 7 Nicotinic Acetylcholine Receptor in Complex with GAT107 and Calcium (Desensitized State) within 5.0Å range: probe atom residue distance (Å) B Occ B:Br601 b:161.3 occ:1.00 BR24 B:YLI601 0.0 161.3 1.0 C21 B:YLI601 1.9 130.0 1.0 C20 B:YLI601 2.9 127.5 1.0 C22 B:YLI601 2.9 128.3 1.0 CD2 B:LEU269 3.7 111.6 1.0 CA B:GLY305 3.8 83.2 1.0 CD1 C:LEU247 3.9 99.2 1.0 CD2 C:LEU247 4.1 98.8 1.0 C19 B:YLI601 4.2 125.7 1.0 C23 B:YLI601 4.2 126.1 1.0 O B:MET301 4.4 106.4 1.0 CG C:LEU247 4.4 95.3 1.0 N B:GLY305 4.4 90.8 1.0 CB C:LEU243 4.5 87.8 1.0 O C:LEU243 4.5 102.6 1.0 CB C:LEU247 4.7 92.6 1.0 CD1 B:LEU269 4.7 110.6 1.0 C18 B:YLI601 4.8 124.5 1.0 CG B:LEU269 4.8 113.1 1.0 C C:LEU243 4.8 91.9 1.0 C B:GLY305 4.9 85.9 1.0

Bromine binding site 3 out of 5 in the Human Alpha 7 Nicotinic Acetylcholine Receptor in Complex with GAT107 and Calcium (Desensitized State)


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 3 of Human Alpha 7 Nicotinic Acetylcholine Receptor in Complex with GAT107 and Calcium (Desensitized State) within 5.0Å range: probe atom residue distance (Å) B Occ C:Br601 b:161.3 occ:1.00 BR24 C:YLI601 0.0 161.3 1.0 C21 C:YLI601 1.9 130.0 1.0 C20 C:YLI601 2.9 127.5 1.0 C22 C:YLI601 2.9 128.3 1.0 CD2 C:LEU269 3.7 111.6 1.0 CA C:GLY305 3.8 83.2 1.0 CD1 D:LEU247 3.9 99.2 1.0 CD2 D:LEU247 4.1 98.8 1.0 C19 C:YLI601 4.2 125.7 1.0 C23 C:YLI601 4.2 126.1 1.0 O C:MET301 4.4 106.4 1.0 CB D:LEU243 4.4 87.8 1.0 O D:LEU243 4.4 102.6 1.0 N C:GLY305 4.4 90.8 1.0 CG D:LEU247 4.4 95.3 1.0 CB D:LEU247 4.7 92.6 1.0 CD1 C:LEU269 4.7 110.6 1.0 C D:LEU243 4.8 91.9 1.0 C18 C:YLI601 4.8 124.5 1.0 CG C:LEU269 4.8 113.1 1.0 C C:GLY305 4.9 85.9 1.0

Bromine binding site 4 out of 5 in the Human Alpha 7 Nicotinic Acetylcholine Receptor in Complex with GAT107 and Calcium (Desensitized State)


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 4 of Human Alpha 7 Nicotinic Acetylcholine Receptor in Complex with GAT107 and Calcium (Desensitized State) within 5.0Å range: probe atom residue distance (Å) B Occ D:Br601 b:161.3 occ:1.00 BR24 D:YLI601 0.0 161.3 1.0 C21 D:YLI601 1.9 130.0 1.0 C20 D:YLI601 2.9 127.5 1.0 C22 D:YLI601 2.9 128.3 1.0 CD2 D:LEU269 3.7 111.6 1.0 CA D:GLY305 3.8 83.2 1.0 CD1 E:LEU247 3.9 99.2 1.0 CD2 E:LEU247 4.1 98.8 1.0 C19 D:YLI601 4.2 125.7 1.0 C23 D:YLI601 4.2 126.1 1.0 O D:MET301 4.3 106.4 1.0 CB E:LEU243 4.4 87.8 1.0 CG E:LEU247 4.4 95.3 1.0 O E:LEU243 4.4 102.6 1.0 N D:GLY305 4.4 90.8 1.0 CB E:LEU247 4.6 92.6 1.0 CD1 D:LEU269 4.7 110.6 1.0 C E:LEU243 4.7 91.9 1.0 C18 D:YLI601 4.8 124.5 1.0 CG D:LEU269 4.8 113.1 1.0 C D:GLY305 4.9 85.9 1.0

Bromine binding site 5 out of 5 in the Human Alpha 7 Nicotinic Acetylcholine Receptor in Complex with GAT107 and Calcium (Desensitized State)


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 5 of Human Alpha 7 Nicotinic Acetylcholine Receptor in Complex with GAT107 and Calcium (Desensitized State) within 5.0Å range: probe atom residue distance (Å) B Occ E:Br601 b:161.3 occ:1.00 BR24 E:YLI601 0.0 161.3 1.0 C21 E:YLI601 1.9 130.0 1.0 C20 E:YLI601 2.9 127.5 1.0 C22 E:YLI601 2.9 128.3 1.0 CD2 E:LEU269 3.7 111.6 1.0 CA E:GLY305 3.8 83.2 1.0 CD1 A:LEU247 3.9 99.2 1.0 CD2 A:LEU247 4.1 98.8 1.0 C19 E:YLI601 4.2 125.7 1.0 C23 E:YLI601 4.2 126.1 1.0 O E:MET301 4.4 106.4 1.0 CG A:LEU247 4.4 95.3 1.0 CB A:LEU243 4.4 87.8 1.0 N E:GLY305 4.4 90.8 1.0 O A:LEU243 4.5 102.6 1.0 CB A:LEU247 4.6 92.6 1.0 CD1 E:LEU269 4.7 110.6 1.0 C18 E:YLI601 4.8 124.5 1.0 C A:LEU243 4.8 91.9 1.0 CG E:LEU269 4.8 113.1 1.0 C E:GLY305 4.9 85.9 1.0

S.Liu, Y.Zheng, H.Chen, X.Li, Q.Yan, W.Mu, Y.Fu, H.Chen, H.Hou, L.Liu, C.Tian. Structural Basis For Allosteric Agonism of Human Alpha 7 Nicotinic Acetylcholine Receptors. Cell Discov V. 11 35 2025.
ISSN: ESSN 2056-5968
PubMed: 40195322
DOI: 10.1038/S41421-025-00788-Y