Bromine in PDB 9j73: Cryo-Em Structure of URAT1 in Complex with Benzbromarone

The binding sites of Bromine atom in the Cryo-Em Structure of URAT1 in Complex with Benzbromarone (pdb code 9j73). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total 2 binding sites of Bromine where determined in the Cryo-Em Structure of URAT1 in Complex with Benzbromarone, PDB code: 9j73:
Jump to Bromine binding site number: 1; 2;

Bromine binding site 1 out of 2 in the Cryo-Em Structure of URAT1 in Complex with Benzbromarone


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Cryo-Em Structure of URAT1 in Complex with Benzbromarone within 5.0Å range: probe atom residue distance (Å) B Occ A:Br601 b:20.0 occ:1.00 BR1 A:R75601 0.0 20.0 1.0 CAD A:R75601 1.9 20.0 1.0 CE2 A:PHE365 2.7 91.9 1.0 CD2 A:PHE365 2.7 91.9 1.0 CAE A:R75601 2.8 20.0 1.0 CAC A:R75601 2.8 20.0 1.0 OAG A:R75601 3.0 20.0 1.0 CZ A:PHE365 3.9 91.9 1.0 CG A:PHE365 3.9 91.9 1.0 CAB A:R75601 4.1 20.0 1.0 CAF A:R75601 4.1 20.0 1.0 CD1 A:LEU153 4.1 71.0 1.0 CB A:ALA480 4.2 91.2 1.0 CAA A:R75601 4.6 20.0 1.0 CA A:ARG477 4.6 97.3 1.0 CB A:PHE365 4.7 91.9 1.0 O A:ALA476 4.7 102.0 1.0 CE1 A:PHE365 4.8 91.9 1.0 C A:ALA476 4.8 102.0 1.0 N A:ARG477 4.8 97.3 1.0 CD1 A:PHE365 4.8 91.9 1.0 CB A:ARG477 4.8 97.3 1.0

Bromine binding site 2 out of 2 in the Cryo-Em Structure of URAT1 in Complex with Benzbromarone


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 2 of Cryo-Em Structure of URAT1 in Complex with Benzbromarone within 5.0Å range: probe atom residue distance (Å) B Occ A:Br601 b:20.0 occ:1.00 BR2 A:R75601 0.0 20.0 1.0 CAB A:R75601 1.9 20.0 1.0 CE A:MET214 2.6 76.7 1.0 CAC A:R75601 2.8 20.0 1.0 CAA A:R75601 2.8 20.0 1.0 OAG A:R75601 3.1 20.0 1.0 NH1 A:ARG477 3.4 97.3 1.0 SD A:MET214 3.8 76.7 1.0 CAD A:R75601 4.1 20.0 1.0 CAF A:R75601 4.2 20.0 1.0 NE2 A:GLN473 4.3 113.5 1.0 CZ A:ARG477 4.6 97.3 1.0 CAE A:R75601 4.7 20.0 1.0 NH2 A:ARG477 4.9 97.3 1.0 CB A:MET214 5.0 76.7 1.0 CG A:MET214 5.0 76.7 1.0

Z.Yu, T.Hu, J.Su, J.Zhao, R.Li, Q.Ma, Q.Chen, Q.Bai, Y.Dong, P.Yuan, N.Li, X.C.Zhang, Y.Zhao. Molecular Mechanism of Drug Inhibition of URAT1. Nat Commun V. 16 6551 2025.
ISSN: ESSN 2041-1723
PubMed: 40670375
DOI: 10.1038/S41467-025-61226-X