Bromine in PDB 1z4u: Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase Complex with Inhibitor Pha-00799585

Enzymatic activity of Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase Complex with Inhibitor Pha-00799585

All present enzymatic activity of Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase Complex with Inhibitor Pha-00799585:
2.7.7.48;

Protein crystallography data

The structure of Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase Complex with Inhibitor Pha-00799585, PDB code: 1z4u was solved by J.A.Pfefferkorn, M.Greene, R.Nugent, R.J.Gross, M.A.Mitchell, B.C.Finzel, M.S.Harris, P.A.Wells, J.A.Shelly, R.Anstadt, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	30.00 / 2.80
*Space group*	P 3₂ 2 1
*Cell size a, b, c (Å), α, β, γ (°)*	91.344, 91.344, 189.111, 90.00, 90.00, 120.00
*R / R_free (%)*	20.8 / 26.5

Other elements in 1z4u:

The structure of Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase Complex with Inhibitor Pha-00799585 also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

Bromine Binding Sites:

The binding sites of Bromine atom in the Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase Complex with Inhibitor Pha-00799585 (pdb code 1z4u). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase Complex with Inhibitor Pha-00799585, PDB code: 1z4u:

Bromine binding site 1 out of 1 in 1z4u

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Bromine Binding Sites List in 1z4u

Bromine binding site 1 out of 1 in the Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase Complex with Inhibitor Pha-00799585

Mono view

Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Hepatitis C Virus NS5B Rna-Dependent Rna Polymerase Complex with Inhibitor Pha-00799585 within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Br600 b:74.2 occ:1.00	BRA2	A:PH9600	0.0	74.2	1.0
	CA2	A:PH9600	1.9	65.4	1.0
	CA1	A:PH9600	2.9	61.5	1.0
	CA3	A:PH9600	2.9	66.9	1.0
	OAB	A:PH9600	3.0	55.9	1.0
	OH	A:TYR448	3.3	65.4	1.0
	O	A:HOH731	3.6	52.9	1.0
	CE	A:MET414	3.7	65.3	1.0
	CB6	A:PH9600	3.8	52.5	1.0
	N	A:PRO197	3.8	59.4	1.0
	CA	A:PRO197	3.8	61.2	1.0
	CD	A:ARG200	3.9	57.5	1.0
	O	A:TYR195	3.9	56.2	1.0
	CB	A:ARG200	4.1	62.7	1.0
	C	A:SER196	4.1	59.2	1.0
	CG	A:PRO197	4.2	60.4	1.0
	CD	A:PRO197	4.2	59.7	1.0
	O	A:SER196	4.2	59.9	1.0
	CA6	A:PH9600	4.2	60.3	1.0
	CA4	A:PH9600	4.3	64.8	1.0
	CB5	A:PH9600	4.3	51.0	1.0
	CZ	A:TYR448	4.4	63.9	1.0
	CE2	A:TYR448	4.5	62.5	1.0
	CG	A:ARG200	4.5	60.1	1.0
	CB4	A:PH9600	4.5	51.1	1.0
	CB	A:PRO197	4.6	60.3	1.0
	C	A:TYR195	4.8	56.4	1.0
	CA	A:SER196	4.8	58.8	1.0
	CA5	A:PH9600	4.8	62.0	1.0
	SD	A:MET414	4.9	67.8	1.0
	C	A:PRO197	5.0	63.2	1.0

Reference:

J.A.Pfefferkorn, R.Nugent, R.J.Gross, M.Greene, M.A.Mitchell, M.T.Reding, L.A.Funk, R.Anderson, P.A.Wells, J.A.Shelly, R.Anstadt, B.C.Finzel, M.S.Harris, R.E.Kilkuskie, L.A.Kopta, F.J.Schwende. Inhibitors of Hcv NS5B Polymerase. Part 2: Evaluation of the Northern Region of (2Z)-2-Benzoylamino-3-(4-Phenoxy-Phenyl)-Acrylic Acid Bioorg.Med.Chem.Lett. V. 15 2812 2005.
ISSN: ISSN 0960-894X
PubMed: 15911260
DOI: 10.1016/J.BMCL.2005.03.106

Page generated: Mon Jul 7 03:59:55 2025

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