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Bromine in PDB 2j5f: Crystal Structure of Egfr Kinase Domain in Complex with An Irreversible Inhibitor 34-Jab

Enzymatic activity of Crystal Structure of Egfr Kinase Domain in Complex with An Irreversible Inhibitor 34-Jab

All present enzymatic activity of Crystal Structure of Egfr Kinase Domain in Complex with An Irreversible Inhibitor 34-Jab:
2.7.10.1;

Protein crystallography data

The structure of Crystal Structure of Egfr Kinase Domain in Complex with An Irreversible Inhibitor 34-Jab, PDB code: 2j5f was solved by C.-H.Yun, M.J.Eck, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.00 / 3.00
Space group I 2 3
Cell size a, b, c (Å), α, β, γ (°) 145.876, 145.876, 145.876, 90.00, 90.00, 90.00
R / Rfree (%) 19 / 24.6

Bromine Binding Sites:

The binding sites of Bromine atom in the Crystal Structure of Egfr Kinase Domain in Complex with An Irreversible Inhibitor 34-Jab (pdb code 2j5f). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Crystal Structure of Egfr Kinase Domain in Complex with An Irreversible Inhibitor 34-Jab, PDB code: 2j5f:

Bromine binding site 1 out of 1 in 2j5f

Go back to Bromine Binding Sites List in 2j5f
Bromine binding site 1 out of 1 in the Crystal Structure of Egfr Kinase Domain in Complex with An Irreversible Inhibitor 34-Jab


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Crystal Structure of Egfr Kinase Domain in Complex with An Irreversible Inhibitor 34-Jab within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Br3021

b:74.8
occ:1.00
 BR A:DJK3021 0.0 74.8 1.0
C3 A:DJK3021 1.9 66.9 1.0
C22 A:DJK3021 2.8 66.4 1.0
C4 A:DJK3021 2.9 66.6 1.0
O A:LEU788 3.1 37.3 1.0
CG2 A:THR790 3.4 35.3 1.0
C A:LEU788 3.4 38.3 1.0
CB A:LEU788 3.6 39.9 1.0
N A:THR790 3.7 36.7 1.0
CB A:THR790 3.7 37.0 1.0
O A:ALA743 3.8 45.2 1.0
N A:ILE789 3.8 37.1 1.0
CB A:LYS745 3.8 55.0 1.0
C A:ILE789 3.9 37.1 1.0
CA A:ILE789 4.0 36.8 1.0
N A:LYS745 4.1 52.5 1.0
C21 A:DJK3021 4.1 64.7 1.0
CA A:LEU788 4.2 39.8 1.0
C5 A:DJK3021 4.2 64.6 1.0
CA A:THR790 4.3 36.7 1.0
C A:ALA743 4.5 44.7 1.0
CA A:LYS745 4.6 55.4 1.0
C20 A:DJK3021 4.7 63.5 1.0
O A:ILE789 4.7 37.3 1.0
CG A:LEU788 4.7 40.1 1.0
N3 A:DJK3021 4.8 62.2 1.0
C A:ILE744 4.8 50.0 1.0
SD A:MET766 4.8 36.1 1.0
CA A:ILE744 4.8 48.1 1.0
OG1 A:THR790 4.9 38.0 1.0
CD A:LYS745 4.9 49.0 1.0
N A:ILE744 5.0 46.6 1.0

Reference:

J.A.Blair, D.Rauh, C.Kung, C.-H.Yun, Q.-W.Fan, H.Rode, C.Zhang, M.J.Eck, W.A.Weiss, K.M.Shokat. Structure-Guided Development of Affinity Probes For Tyrosine Kinases Using Chemical Genetics. Nat.Chem.Biol. V. 3 229 2007.
ISSN: ISSN 1552-4450
PubMed: 17334377
DOI: 10.1038/NCHEMBIO866
Page generated: Mon Jul 7 04:23:16 2025

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