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Bromine in PDB 4gw6: Hiv-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor
Enzymatic activity of Hiv-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor
All present enzymatic activity of Hiv-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor:
2.7.7.49; 2.7.7.7; 3.1.13.2; 3.1.26.13; 3.4.23.16;
2.7.7.49; 2.7.7.7; 3.1.13.2; 3.1.26.13; 3.4.23.16;
Protein crystallography data
The structure of Hiv-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor, PDB code: 4gw6
was solved by
L.Feng,
M.Kvaratskhelia,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 20.60 / 2.65 |
| Space group | P 31 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 72.769, 72.769, 65.379, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 19.4 / 23.8 |
Other elements in 4gw6:
The structure of Hiv-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor also contains other interesting chemical elements:
| Arsenic | (As) | 2 atoms |
| Chlorine | (Cl) | 1 atom |
Bromine Binding Sites:
The binding sites of Bromine atom in the Hiv-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor
(pdb code 4gw6). This binding sites where shown within
5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Hiv-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor, PDB code: 4gw6:
In total only one binding site of Bromine was determined in the Hiv-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor, PDB code: 4gw6:
Bromine binding site 1 out of 1 in 4gw6
Go back to
Bromine Binding Sites List in 4gw6
Bromine binding site 1 out
of 1 in the Hiv-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Bromine with other atoms in the Br binding
site number 1 of Hiv-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor within 5.0Å range:
|
Reference:
L.Feng,
A.Sharma,
A.Slaughter,
N.Jena,
Y.Koh,
N.Shkriabai,
R.C.Larue,
P.A.Patel,
H.Mitsuya,
J.J.Kessl,
A.Engelman,
J.R.Fuchs,
M.Kvaratskhelia.
The A128T Resistance Mutation Reveals Aberrant Protein Multimerization As the Primary Mechanism of Action of Allosteric Hiv-1 Integrase Inhibitors. J.Biol.Chem. V. 288 15813 2013.
ISSN: ISSN 0021-9258
PubMed: 23615903
DOI: 10.1074/JBC.M112.443390
Page generated: Mon Jul 7 06:40:58 2025
ISSN: ISSN 0021-9258
PubMed: 23615903
DOI: 10.1074/JBC.M112.443390
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