Bromine in PDB 5dyc: Crystal Structure of the Human BRPF1 Bromodomain in Complex with SEED6

The structure of Crystal Structure of the Human BRPF1 Bromodomain in Complex with SEED6, PDB code: 5dyc was solved by J.Zhu, A.Caflisch, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.40 / 1.65
Space group	P 32 2 1
Cell size a, b, c (Å), α, β, γ (°)	60.808, 60.808, 63.116, 90.00, 90.00, 120.00
R / Rfree (%)	19.9 / 23.5

The binding sites of Bromine atom in the Crystal Structure of the Human BRPF1 Bromodomain in Complex with SEED6 (pdb code 5dyc). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Crystal Structure of the Human BRPF1 Bromodomain in Complex with SEED6, PDB code: 5dyc:

Bromine binding site 1 out of 1 in the Crystal Structure of the Human BRPF1 Bromodomain in Complex with SEED6


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Crystal Structure of the Human BRPF1 Bromodomain in Complex with SEED6 within 5.0Å range: probe atom residue distance (Å) B Occ A:Br802 b:74.0 occ:1.00 BR A:5GU802 0.0 74.0 1.0 CAJ A:5GU802 1.9 63.4 1.0 CAE A:5GU802 2.8 58.5 1.0 CAC A:5GU802 2.8 61.8 1.0 OE1 A:GLU661 3.1 92.7 1.0 CD A:GLU661 3.9 93.7 1.0 CB A:GLU661 4.1 76.8 1.0 CG A:PRO658 4.1 63.7 1.0 CAL A:5GU802 4.1 52.5 1.0 CAD A:5GU802 4.1 56.7 1.0 CG2 A:VAL662 4.4 61.8 1.0 OE2 A:GLU661 4.6 99.8 1.0 CD A:PRO658 4.6 60.6 1.0 CG A:GLU661 4.6 86.7 1.0 CZ A:PHE714 4.6 53.0 1.0 CAK A:5GU802 4.6 51.2 1.0 CE2 A:PHE714 4.8 52.3 1.0

J.Zhu, A.Caflisch. Twenty Crystal Structures of Bromodomain and Phd Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions. J.Med.Chem. V. 59 5555 2016.
ISSN: ISSN 0022-2623
PubMed: 27167503
DOI: 10.1021/ACS.JMEDCHEM.6B00215