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Atomistry » Bromine » PDB 5ev3-5i5p » 5fi8 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Bromine » PDB 5ev3-5i5p » 5fi8 » |
Bromine in PDB 5fi8: Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bounded with DSM422 (Tetrahydro-2-Naphthyl and 2- Indanyl Triazolopyrimidine)Enzymatic activity of Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bounded with DSM422 (Tetrahydro-2-Naphthyl and 2- Indanyl Triazolopyrimidine)
All present enzymatic activity of Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bounded with DSM422 (Tetrahydro-2-Naphthyl and 2- Indanyl Triazolopyrimidine):
1.3.5.2; Protein crystallography data
The structure of Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bounded with DSM422 (Tetrahydro-2-Naphthyl and 2- Indanyl Triazolopyrimidine), PDB code: 5fi8
was solved by
X.Deng,
S.Kokkonda,
D.Tomchick,
M.Phillips,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5fi8:
The structure of Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bounded with DSM422 (Tetrahydro-2-Naphthyl and 2- Indanyl Triazolopyrimidine) also contains other interesting chemical elements:
Bromine Binding Sites:
The binding sites of Bromine atom in the Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bounded with DSM422 (Tetrahydro-2-Naphthyl and 2- Indanyl Triazolopyrimidine)
(pdb code 5fi8). This binding sites where shown within
5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bounded with DSM422 (Tetrahydro-2-Naphthyl and 2- Indanyl Triazolopyrimidine), PDB code: 5fi8: Bromine binding site 1 out of 1 in 5fi8Go back to![]() ![]()
Bromine binding site 1 out
of 1 in the Crystal Structure of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bounded with DSM422 (Tetrahydro-2-Naphthyl and 2- Indanyl Triazolopyrimidine)
![]() Mono view ![]() Stereo pair view
Reference:
S.Kokkonda,
X.Deng,
K.L.White,
J.M.Coteron,
M.Marco,
L.De Las Heras,
J.White,
F.El Mazouni,
D.R.Tomchick,
K.Manjalanagara,
K.R.Rudra,
G.Chen,
J.Morizzi,
E.Ryan,
W.Kaminsky,
D.Leroy,
M.S.Martinez-Martinez,
M.B.Jimenez-Diaz,
S.F.Bazaga,
I.Angulo-Barturen,
D.Waterson,
J.N.Burrows,
D.Matthews,
S.A.Charman,
M.A.Phillips,
P.K.Rathod.
Tetrahydro-2-Naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium Falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity. J.Med.Chem. V. 59 5416 2016.
Page generated: Mon Jul 7 08:15:24 2025
ISSN: ISSN 0022-2623 PubMed: 27127993 DOI: 10.1021/ACS.JMEDCHEM.6B00275 |
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