Bromine in PDB 5ifc: Crystal Structure of Polymerase Acid Protein (Pa) From Influenza A Virus, Wilson-Smith/1933 (H1N1) Bound to Follow on Fragment Ebsi-4720 1-(4-Bromophenyl)-1H-Imidazole

The structure of Crystal Structure of Polymerase Acid Protein (Pa) From Influenza A Virus, Wilson-Smith/1933 (H1N1) Bound to Follow on Fragment Ebsi-4720 1-(4-Bromophenyl)-1H-Imidazole, PDB code: 5ifc was solved by Seattle Structural Genomics Center For Infectious Disease (Ssgcid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	41.21 / 2.65
Space group	P 65 2 2
Cell size a, b, c (Å), α, β, γ (°)	69.080, 69.080, 397.970, 90.00, 90.00, 120.00
R / Rfree (%)	17.8 / 23.4

The binding sites of Bromine atom in the Crystal Structure of Polymerase Acid Protein (Pa) From Influenza A Virus, Wilson-Smith/1933 (H1N1) Bound to Follow on Fragment Ebsi-4720 1-(4-Bromophenyl)-1H-Imidazole (pdb code 5ifc). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Crystal Structure of Polymerase Acid Protein (Pa) From Influenza A Virus, Wilson-Smith/1933 (H1N1) Bound to Follow on Fragment Ebsi-4720 1-(4-Bromophenyl)-1H-Imidazole, PDB code: 5ifc:

Bromine binding site 1 out of 1 in the Crystal Structure of Polymerase Acid Protein (Pa) From Influenza A Virus, Wilson-Smith/1933 (H1N1) Bound to Follow on Fragment Ebsi-4720 1-(4-Bromophenyl)-1H-Imidazole


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Crystal Structure of Polymerase Acid Protein (Pa) From Influenza A Virus, Wilson-Smith/1933 (H1N1) Bound to Follow on Fragment Ebsi-4720 1-(4-Bromophenyl)-1H-Imidazole within 5.0Å range: probe atom residue distance (Å) B Occ A:Br801 b:88.8 occ:1.00 BR A:6AR801 0.0 88.8 1.0 C02 A:6AR801 2.0 60.5 1.0 C03 A:6AR801 2.9 54.0 1.0 C07 A:6AR801 2.9 51.5 1.0 OE1 A:GLU349 3.2 61.5 1.0 CB A:MET311 3.7 34.1 1.0 CD A:GLU349 3.8 67.6 1.0 NE A:ARG312 4.0 55.9 1.0 CG2 A:ILE308 4.1 43.0 1.0 CB A:LEU345 4.1 35.5 1.0 OE2 A:GLU349 4.1 67.7 1.0 C04 A:6AR801 4.2 51.2 1.0 C06 A:6AR801 4.2 52.5 1.0 CG A:MET311 4.2 29.9 1.0 O A:ILE308 4.3 44.0 1.0 CG A:ARG312 4.3 39.7 1.0 CA A:ILE308 4.4 40.8 1.0 CD A:ARG312 4.5 46.7 1.0 CG1 A:ILE308 4.5 37.2 1.0 CZ A:ARG312 4.5 58.5 1.0 CB A:ILE308 4.5 41.3 1.0 CD1 A:LEU345 4.6 27.4 1.0 NH2 A:ARG312 4.7 58.3 1.0 C05 A:6AR801 4.7 49.8 1.0 C A:LEU345 4.8 41.4 1.0 O A:LEU345 4.8 48.4 1.0 CE A:MET311 4.8 27.5 1.0 C A:ILE308 4.8 40.2 1.0 CG A:GLU349 4.8 72.5 1.0 CG A:LEU345 4.9 41.4 1.0

P.Pierce, M.M.Muruthi, J.Abendroth, S.O.Moen, D.W.Begley, D.R.Davies, V.M.Marathias, B.L.Staker, P.J.Myler, D.D.Lorimer, T.E.Edwards. Fragment Screening By Std uc(Nmr) Identifies Novel Site Binders Against Influenza A Virus Polymerase Pa To Be Published.