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Bromine in PDB 5l79: Crystal Structure of MMP12 in Complex with RXP470.1 Conjugated with Fluorophore CY5,5 in Space Group P21212.

Enzymatic activity of Crystal Structure of MMP12 in Complex with RXP470.1 Conjugated with Fluorophore CY5,5 in Space Group P21212.

All present enzymatic activity of Crystal Structure of MMP12 in Complex with RXP470.1 Conjugated with Fluorophore CY5,5 in Space Group P21212.:
3.4.24.65;

Protein crystallography data

The structure of Crystal Structure of MMP12 in Complex with RXP470.1 Conjugated with Fluorophore CY5,5 in Space Group P21212., PDB code: 5l79 was solved by L.Tepshi, T.Bordenave, L.Devel, V.Dive, E.A.Stura, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.01 / 2.07
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 70.900, 62.790, 37.740, 90.00, 90.00, 90.00
R / Rfree (%) 20.6 / 24.1

Other elements in 5l79:

The structure of Crystal Structure of MMP12 in Complex with RXP470.1 Conjugated with Fluorophore CY5,5 in Space Group P21212. also contains other interesting chemical elements:

Zinc (Zn) 2 atoms
Calcium (Ca) 3 atoms
Chlorine (Cl) 1 atom

Bromine Binding Sites:

The binding sites of Bromine atom in the Crystal Structure of MMP12 in Complex with RXP470.1 Conjugated with Fluorophore CY5,5 in Space Group P21212. (pdb code 5l79). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Crystal Structure of MMP12 in Complex with RXP470.1 Conjugated with Fluorophore CY5,5 in Space Group P21212., PDB code: 5l79:

Bromine binding site 1 out of 1 in 5l79

Go back to Bromine Binding Sites List in 5l79
Bromine binding site 1 out of 1 in the Crystal Structure of MMP12 in Complex with RXP470.1 Conjugated with Fluorophore CY5,5 in Space Group P21212.


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Crystal Structure of MMP12 in Complex with RXP470.1 Conjugated with Fluorophore CY5,5 in Space Group P21212. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Br306

b:30.4
occ:0.30
BR1 A:R47306 0.0 30.4 0.3
C22 A:R47306 1.9 31.3 1.0
C21 A:R47306 2.8 31.5 1.0
C23 A:R47306 2.9 30.1 1.0
O A:HOH416 3.8 38.4 1.0
C20 A:R47306 4.2 31.2 1.0
C24 A:R47306 4.2 29.9 1.0
ND1 A:HIS172 4.3 52.9 1.0
CE1 A:HIS172 4.6 53.7 1.0
C19 A:R47306 4.7 30.5 1.0

Reference:

T.Bordenave, M.Helle, F.Beau, D.Georgiadis, L.Tepshi, M.Bernes, Y.Ye, L.Levenez, E.Poquet, H.Nozach, M.Razavian, J.Toczek, E.A.Stura, V.Dive, M.M.Sadeghi, L.Devel. Synthesis and in Vitro and in Vivo Evaluation of Mmp-12 Selective Optical Probes. Bioconjug.Chem. V. 27 2407 2016.
ISSN: ISSN 1043-1802
PubMed: 27564088
DOI: 10.1021/ACS.BIOCONJCHEM.6B00377
Page generated: Thu Jul 11 00:10:06 2024

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