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Atomistry » Bromine » PDB 5mrm-5o0j » 5nb7 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Bromine » PDB 5mrm-5o0j » 5nb7 » |
Bromine in PDB 5nb7: Complement Factor DEnzymatic activity of Complement Factor D
All present enzymatic activity of Complement Factor D:
3.4.21.46; Protein crystallography data
The structure of Complement Factor D, PDB code: 5nb7
was solved by
A.Mac Sweeney,
N.Ostermann,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Bromine Binding Sites:
The binding sites of Bromine atom in the Complement Factor D
(pdb code 5nb7). This binding sites where shown within
5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Complement Factor D, PDB code: 5nb7: Bromine binding site 1 out of 1 in 5nb7Go back to![]() ![]()
Bromine binding site 1 out
of 1 in the Complement Factor D
![]() Mono view ![]() Stereo pair view
Reference:
E.Lorthiois,
K.Anderson,
A.Vulpetti,
O.Rogel,
F.Cumin,
N.Ostermann,
S.Steinbacher,
A.Mac Sweeney,
O.Delgado,
S.M.Liao,
S.Randl,
S.Rudisser,
S.Dussauge,
K.Fettis,
L.Kieffer,
A.De Erkenez,
L.Yang,
C.Hartwieg,
U.A.Argikar,
L.R.La Bonte,
R.Newton,
V.Kansara,
S.Flohr,
U.Hommel,
B.Jaffee,
J.Maibaum.
Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo. J. Med. Chem. V. 60 5717 2017.
Page generated: Mon Jul 7 08:48:10 2025
ISSN: ISSN 1520-4804 PubMed: 28621538 DOI: 10.1021/ACS.JMEDCHEM.7B00425 |
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