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Atomistry » Bromine » PDB 5mrm-5o0j » 5np8 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Bromine » PDB 5mrm-5o0j » 5np8 » |
Bromine in PDB 5np8: PGK1 in Complex with CRT0063465 (3-[2-(4-Bromophenyl)-5,7-Dimethyl- Pyrazolo[1,5-A]Pyrimidin-6-Yl]Propanoic Acid)Enzymatic activity of PGK1 in Complex with CRT0063465 (3-[2-(4-Bromophenyl)-5,7-Dimethyl- Pyrazolo[1,5-A]Pyrimidin-6-Yl]Propanoic Acid)
All present enzymatic activity of PGK1 in Complex with CRT0063465 (3-[2-(4-Bromophenyl)-5,7-Dimethyl- Pyrazolo[1,5-A]Pyrimidin-6-Yl]Propanoic Acid):
2.7.2.3; Protein crystallography data
The structure of PGK1 in Complex with CRT0063465 (3-[2-(4-Bromophenyl)-5,7-Dimethyl- Pyrazolo[1,5-A]Pyrimidin-6-Yl]Propanoic Acid), PDB code: 5np8
was solved by
A.P.Turnbull,
A.E.Bilsland,
Y.Liu,
D.Sumpton,
K.Stevenson,
C.J.Cairney,
J.Roffey,
D.Jenkinson,
W.N.Keith,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Bromine Binding Sites:
The binding sites of Bromine atom in the PGK1 in Complex with CRT0063465 (3-[2-(4-Bromophenyl)-5,7-Dimethyl- Pyrazolo[1,5-A]Pyrimidin-6-Yl]Propanoic Acid)
(pdb code 5np8). This binding sites where shown within
5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the PGK1 in Complex with CRT0063465 (3-[2-(4-Bromophenyl)-5,7-Dimethyl- Pyrazolo[1,5-A]Pyrimidin-6-Yl]Propanoic Acid), PDB code: 5np8: Bromine binding site 1 out of 1 in 5np8Go back to![]() ![]()
Bromine binding site 1 out
of 1 in the PGK1 in Complex with CRT0063465 (3-[2-(4-Bromophenyl)-5,7-Dimethyl- Pyrazolo[1,5-A]Pyrimidin-6-Yl]Propanoic Acid)
![]() Mono view ![]() Stereo pair view
Reference:
A.E.Bilsland,
Y.Liu,
A.Turnbull,
D.Sumpton,
K.Stevenson,
C.J.Cairney,
S.M.Boyd,
J.Roffey,
D.Jenkinson,
W.N.Keith.
A Novel Pyrazolopyrimidine Ligand of Human PGK1 and Stress Sensor DJ1 Modulates the Shelterin Complex and Telomere Length Regulation. Neoplasia V. 21 893 2019.
Page generated: Mon Jul 7 08:50:30 2025
ISSN: ISSN 1476-5586 PubMed: 31401411 DOI: 10.1016/J.NEO.2019.07.008 |
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