Bromine in PDB 7mcu: Crystal Structure of Staphylococcus Aureus Cystathionine Gamma Lyase, Holoenzyme with Bound NL2

Enzymatic activity of Crystal Structure of Staphylococcus Aureus Cystathionine Gamma Lyase, Holoenzyme with Bound NL2

All present enzymatic activity of Crystal Structure of Staphylococcus Aureus Cystathionine Gamma Lyase, Holoenzyme with Bound NL2:
2.5.1.48; 4.4.1.1; 4.4.1.8;

Protein crystallography data

The structure of Crystal Structure of Staphylococcus Aureus Cystathionine Gamma Lyase, Holoenzyme with Bound NL2, PDB code: 7mcu was solved by A.Nuthanakanti, A.Serganov, A.Kaushik, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	28.94 / 2.40
*Space group*	I 4₁ 2 2
*Cell size a, b, c (Å), α, β, γ (°)*	104.89, 104.89, 288.27, 90, 90, 90
*R / R_free (%)*	15.7 / 19.4

Other elements in 7mcu:

The structure of Crystal Structure of Staphylococcus Aureus Cystathionine Gamma Lyase, Holoenzyme with Bound NL2 also contains other interesting chemical elements:

Sodium

(Na)

2 atoms

Bromine Binding Sites:

The binding sites of Bromine atom in the Crystal Structure of Staphylococcus Aureus Cystathionine Gamma Lyase, Holoenzyme with Bound NL2 (pdb code 7mcu). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Crystal Structure of Staphylococcus Aureus Cystathionine Gamma Lyase, Holoenzyme with Bound NL2, PDB code: 7mcu:

Bromine binding site 1 out of 1 in 7mcu

Go back to

Bromine Binding Sites List in 7mcu

Bromine binding site 1 out of 1 in the Crystal Structure of Staphylococcus Aureus Cystathionine Gamma Lyase, Holoenzyme with Bound NL2

Mono view

Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Crystal Structure of Staphylococcus Aureus Cystathionine Gamma Lyase, Holoenzyme with Bound NL2 within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
H:Br402 b:116.2 occ:0.75	BR	H:YXA402	0.0	116.2	0.8
	C6	H:YXA402	1.9	72.3	0.8
	C7	H:YXA402	2.8	63.7	0.8
	C5	H:YXA402	2.9	65.4	0.8
	CG	H:GLU350	3.5	61.3	1.0
	CB	H:GLU350	3.5	49.4	1.0
	CG1	H:ILE352	3.9	28.1	1.0
	CD2	H:HIS339	4.0	47.2	1.0
	CD1	H:ILE342	4.1	51.9	1.0
	C8	H:YXA402	4.1	58.8	0.8
	C4	H:YXA402	4.2	54.9	0.8
	CA	H:ARG347	4.5	41.7	1.0
	CG2	H:ILE342	4.5	54.3	1.0
	O	H:ILE346	4.6	43.0	1.0
	C9	H:YXA402	4.6	58.4	0.8
	CD	H:GLU350	4.7	66.7	1.0
	CG1	H:ILE342	4.7	50.9	1.0
	CG	H:ARG347	4.8	43.8	1.0
	CB	H:ILE352	4.8	38.9	1.0
	NE2	H:HIS339	4.8	52.2	1.0
	CD1	H:ILE352	4.9	29.4	1.0
	CB	H:ILE342	4.9	52.4	1.0
	CA	H:GLU350	5.0	47.0	1.0

Reference:

K.Shatalin, A.Nuthanakanti, A.Kaushik, D.Shishov, A.Peselis, I.Shamovsky, B.Pani, M.Lechpammer, N.Vasilyev, E.Shatalina, D.Rebatchouk, A.Mironov, P.Fedichev, A.Serganov, E.Nudler. Inhibitors of Bacterial H 2 S Biogenesis Targeting Antibiotic Resistance and Tolerance. Science V. 372 1169 2021.
ISSN: ESSN 1095-9203
PubMed: 34112687
DOI: 10.1126/SCIENCE.ABD8377

Page generated: Thu Jul 11 04:05:46 2024

Last articles

Zn in 9MJ5
Zn in 9HNW
Zn in 9G0L
Zn in 9FNE
Zn in 9DZN
Zn in 9E0I
Zn in 9D32
Zn in 9DAK
Zn in 8ZXC
Zn in 8ZUF

	© Copyright 2008-2020 by atomistry.com
Home \| Site Map \| Copyright \| Contact us \| Privacy