Bromine in PDB 7t0y: The Ribosomal Rna Processing 1B Protein Phosphatase-1 Holoenzyme

All present enzymatic activity of The Ribosomal Rna Processing 1B Protein Phosphatase-1 Holoenzyme:
3.1.3.16;

The structure of The Ribosomal Rna Processing 1B Protein Phosphatase-1 Holoenzyme, PDB code: 7t0y was solved by G.Srivastava, R.Page, W.Peti, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.27 / 1.80
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	83.528, 160.387, 50.615, 90, 90, 90
R / Rfree (%)	20.8 / 24.6

The structure of The Ribosomal Rna Processing 1B Protein Phosphatase-1 Holoenzyme also contains other interesting chemical elements:

Manganese	(Mn)	4 atoms
Fluorine	(F)	1 atom

The binding sites of Bromine atom in the The Ribosomal Rna Processing 1B Protein Phosphatase-1 Holoenzyme (pdb code 7t0y). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total 3 binding sites of Bromine where determined in the The Ribosomal Rna Processing 1B Protein Phosphatase-1 Holoenzyme, PDB code: 7t0y:
Jump to Bromine binding site number: 1; 2; 3;

Bromine binding site 1 out of 3 in the The Ribosomal Rna Processing 1B Protein Phosphatase-1 Holoenzyme


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of The Ribosomal Rna Processing 1B Protein Phosphatase-1 Holoenzyme within 5.0Å range: probe atom residue distance (Å) B Occ A:Br409 b:36.5 occ:0.69 O A:HOH677 3.0 30.2 1.0 O A:HOH710 3.1 36.7 1.0 N A:ALA259 3.5 25.0 1.0 CD1 A:PHE258 3.8 25.2 1.0 CA A:PHE258 4.1 19.9 1.0 CB A:LYS211 4.2 23.3 1.0 CE1 A:PHE258 4.3 25.1 1.0 C A:PHE258 4.3 21.1 1.0 CD A:LYS211 4.4 25.2 1.0 CA A:ALA259 4.4 21.0 1.0 CG A:PHE258 4.5 21.8 1.0 O A:PHE257 4.8 24.2 1.0 CB A:PHE258 4.8 21.2 1.0 O A:HOH647 4.9 24.6 1.0 CG A:LYS211 4.9 21.4 1.0

Bromine binding site 2 out of 3 in the The Ribosomal Rna Processing 1B Protein Phosphatase-1 Holoenzyme


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 2 of The Ribosomal Rna Processing 1B Protein Phosphatase-1 Holoenzyme within 5.0Å range: probe atom residue distance (Å) B Occ A:Br410 b:61.4 occ:0.64 NZ A:LYS150 3.1 43.6 1.0 CE A:LYS150 3.5 30.3 1.0 CD A:LYS150 3.6 36.4 1.0 CG2 A:ILE146 4.3 26.4 1.0 CA A:LYS147 4.7 19.4 1.0 N A:LYS147 4.8 19.3 1.0 CG A:LYS150 4.8 28.3 1.0 CB A:LYS147 4.9 21.4 1.0

Bromine binding site 3 out of 3 in the The Ribosomal Rna Processing 1B Protein Phosphatase-1 Holoenzyme


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 3 of The Ribosomal Rna Processing 1B Protein Phosphatase-1 Holoenzyme within 5.0Å range: probe atom residue distance (Å) B Occ C:Br409 b:42.0 occ:0.64 O C:HOH606 3.0 31.8 1.0 O C:HOH692 3.2 35.5 1.0 N C:ALA259 3.4 31.3 1.0 CD1 C:PHE258 3.8 24.8 1.0 CA C:PHE258 4.1 23.0 1.0 C C:PHE258 4.3 27.8 1.0 CE1 C:PHE258 4.3 26.1 1.0 CA C:ALA259 4.3 27.8 1.0 CB C:LYS211 4.3 26.7 1.0 CG C:PHE258 4.5 26.4 1.0 CD C:LYS211 4.6 35.6 1.0 O C:HOH661 4.7 31.4 1.0 CB C:PHE258 4.8 18.8 1.0 O C:PHE257 4.9 24.8 1.0 CG C:LYS211 4.9 26.2 1.0 N C:LYS260 5.0 29.9 1.0

G.Srivastava, R.Bajaj, G.S.Kumar, A.Gaudreau-Lapierre, H.Nicolas, D.Chamousset, D.Kreitler, W.Peti, L.Trinkle-Mulcahy, R.Page. The Ribosomal Rna Processing 1B:Protein Phosphatase 1 Holoenzyme Reveals Non-Canonical PP1 Interaction Motifs. Cell Rep V. 41 11726 2022.
ISSN: ESSN 2211-1247
PubMed: 36450254
DOI: 10.1016/J.CELREP.2022.111726