Bromine in PDB 8e6t: Human TRPM2 Ion Channel in 1 Mm Br-Adpr

The binding sites of Bromine atom in the Human TRPM2 Ion Channel in 1 Mm Br-Adpr (pdb code 8e6t). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total 8 binding sites of Bromine where determined in the Human TRPM2 Ion Channel in 1 Mm Br-Adpr, PDB code: 8e6t:
Jump to Bromine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Bromine binding site 1 out of 8 in the Human TRPM2 Ion Channel in 1 Mm Br-Adpr


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Human TRPM2 Ion Channel in 1 Mm Br-Adpr within 5.0Å range: probe atom residue distance (Å) B Occ A:Br1601 b:80.5 occ:1.00 BR10 A:UOO1601 0.0 80.5 1.0 C09 A:UOO1601 1.9 80.5 1.0 N11 A:UOO1601 2.9 80.5 1.0 N08 A:UOO1601 2.9 80.5 1.0 C12 A:UOO1601 3.3 80.5 1.0 O37 A:UOO1601 3.4 80.5 1.0 O A:ASN273 3.9 38.5 1.0 CE2 A:TYR295 4.1 57.2 1.0 OG1 A:THR275 4.1 43.0 1.0 C06 A:UOO1601 4.1 80.5 1.0 C07 A:UOO1601 4.1 80.5 1.0 OH A:TYR295 4.2 57.2 1.0 CZ A:TYR295 4.6 57.2 1.0 C13 A:UOO1601 4.9 80.5 1.0 C A:ASN273 5.0 38.5 1.0

Bromine binding site 2 out of 8 in the Human TRPM2 Ion Channel in 1 Mm Br-Adpr


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 2 of Human TRPM2 Ion Channel in 1 Mm Br-Adpr within 5.0Å range: probe atom residue distance (Å) B Occ A:Br1602 b:127.8 occ:1.00 BR10 A:UOO1602 0.0 127.8 1.0 C09 A:UOO1602 1.9 127.8 1.0 N11 A:UOO1602 2.9 127.8 1.0 N08 A:UOO1602 2.9 127.8 1.0 O14 A:UOO1602 3.1 127.8 1.0 C13 A:UOO1602 3.3 127.8 1.0 C12 A:UOO1602 3.4 127.8 1.0 CG A:PRO1432 3.5 65.5 1.0 CE1 A:TYR1485 3.7 74.4 1.0 CD1 A:TYR1485 4.1 74.4 1.0 C07 A:UOO1602 4.1 127.8 1.0 C06 A:UOO1602 4.1 127.8 1.0 CB A:PRO1432 4.4 65.5 1.0 CZ A:TYR1485 4.5 74.4 1.0 CD A:PRO1432 4.6 65.5 1.0 O37 A:UOO1602 4.7 127.8 1.0 OH A:TYR1485 4.8 74.4 1.0 C15 A:UOO1602 4.9 127.8 1.0

Bromine binding site 3 out of 8 in the Human TRPM2 Ion Channel in 1 Mm Br-Adpr


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 3 of Human TRPM2 Ion Channel in 1 Mm Br-Adpr within 5.0Å range: probe atom residue distance (Å) B Occ B:Br1601 b:83.7 occ:1.00 BR10 B:UOO1601 0.0 83.7 1.0 C09 B:UOO1601 1.9 83.7 1.0 N11 B:UOO1601 2.9 83.7 1.0 N08 B:UOO1601 2.9 83.7 1.0 C12 B:UOO1601 3.3 83.7 1.0 O37 B:UOO1601 3.4 83.7 1.0 O B:ASN273 3.9 50.3 1.0 CE2 B:TYR295 4.1 59.7 1.0 OG1 B:THR275 4.1 59.1 1.0 C06 B:UOO1601 4.1 83.7 1.0 C07 B:UOO1601 4.1 83.7 1.0 OH B:TYR295 4.2 59.7 1.0 CZ B:TYR295 4.6 59.7 1.0 C13 B:UOO1601 4.9 83.7 1.0 C B:ASN273 5.0 50.3 1.0

Bromine binding site 4 out of 8 in the Human TRPM2 Ion Channel in 1 Mm Br-Adpr


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 4 of Human TRPM2 Ion Channel in 1 Mm Br-Adpr within 5.0Å range: probe atom residue distance (Å) B Occ B:Br1602 b:133.0 occ:1.00 BR10 B:UOO1602 0.0 133.0 1.0 C09 B:UOO1602 1.9 133.0 1.0 N08 B:UOO1602 2.9 133.0 1.0 N11 B:UOO1602 2.9 133.0 1.0 O14 B:UOO1602 3.1 133.0 1.0 C13 B:UOO1602 3.3 133.0 1.0 C12 B:UOO1602 3.4 133.0 1.0 CG B:PRO1432 3.5 69.6 1.0 CE1 B:TYR1485 3.7 72.6 1.0 CD1 B:TYR1485 4.1 72.6 1.0 C07 B:UOO1602 4.1 133.0 1.0 C06 B:UOO1602 4.1 133.0 1.0 CB B:PRO1432 4.4 69.6 1.0 CZ B:TYR1485 4.5 72.6 1.0 CD B:PRO1432 4.6 69.6 1.0 O37 B:UOO1602 4.7 133.0 1.0 OH B:TYR1485 4.8 72.6 1.0 C15 B:UOO1602 4.9 133.0 1.0

Bromine binding site 5 out of 8 in the Human TRPM2 Ion Channel in 1 Mm Br-Adpr


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 5 of Human TRPM2 Ion Channel in 1 Mm Br-Adpr within 5.0Å range: probe atom residue distance (Å) B Occ C:Br1601 b:77.0 occ:1.00 BR10 C:UOO1601 0.0 77.0 1.0 C09 C:UOO1601 1.9 77.0 1.0 N11 C:UOO1601 2.9 77.0 1.0 N08 C:UOO1601 2.9 77.0 1.0 C12 C:UOO1601 3.3 77.0 1.0 O37 C:UOO1601 3.4 77.0 1.0 O C:ASN273 3.9 44.0 1.0 CE2 C:TYR295 4.1 61.4 1.0 OG1 C:THR275 4.1 55.9 1.0 C06 C:UOO1601 4.1 77.0 1.0 C07 C:UOO1601 4.1 77.0 1.0 OH C:TYR295 4.2 61.4 1.0 CZ C:TYR295 4.6 61.4 1.0 C13 C:UOO1601 4.9 77.0 1.0 C C:ASN273 5.0 44.0 1.0

Bromine binding site 6 out of 8 in the Human TRPM2 Ion Channel in 1 Mm Br-Adpr


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 6 of Human TRPM2 Ion Channel in 1 Mm Br-Adpr within 5.0Å range: probe atom residue distance (Å) B Occ C:Br1602 b:130.8 occ:1.00 BR10 C:UOO1602 0.0 130.8 1.0 C09 C:UOO1602 1.9 130.8 1.0 N11 C:UOO1602 2.9 130.8 1.0 N08 C:UOO1602 2.9 130.8 1.0 O14 C:UOO1602 3.1 130.8 1.0 C13 C:UOO1602 3.3 130.8 1.0 C12 C:UOO1602 3.4 130.8 1.0 CG C:PRO1432 3.5 69.1 1.0 CE1 C:TYR1485 3.7 75.8 1.0 CD1 C:TYR1485 4.1 75.8 1.0 C07 C:UOO1602 4.1 130.8 1.0 C06 C:UOO1602 4.1 130.8 1.0 CB C:PRO1432 4.4 69.1 1.0 CZ C:TYR1485 4.5 75.8 1.0 CD C:PRO1432 4.6 69.1 1.0 O37 C:UOO1602 4.7 130.8 1.0 OH C:TYR1485 4.9 75.8 1.0 C15 C:UOO1602 4.9 130.8 1.0

Bromine binding site 7 out of 8 in the Human TRPM2 Ion Channel in 1 Mm Br-Adpr


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 7 of Human TRPM2 Ion Channel in 1 Mm Br-Adpr within 5.0Å range: probe atom residue distance (Å) B Occ D:Br1601 b:78.4 occ:1.00 BR10 D:UOO1601 0.0 78.4 1.0 C09 D:UOO1601 1.9 78.4 1.0 N11 D:UOO1601 2.9 78.4 1.0 N08 D:UOO1601 2.9 78.4 1.0 C12 D:UOO1601 3.3 78.4 1.0 O37 D:UOO1601 3.4 78.4 1.0 O D:ASN273 3.9 53.5 1.0 CE2 D:TYR295 4.1 61.3 1.0 C06 D:UOO1601 4.1 78.4 1.0 OG1 D:THR275 4.1 61.2 1.0 C07 D:UOO1601 4.1 78.4 1.0 OH D:TYR295 4.2 61.3 1.0 CZ D:TYR295 4.6 61.3 1.0 C13 D:UOO1601 4.9 78.4 1.0 C D:ASN273 5.0 53.5 1.0

Bromine binding site 8 out of 8 in the Human TRPM2 Ion Channel in 1 Mm Br-Adpr


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 8 of Human TRPM2 Ion Channel in 1 Mm Br-Adpr within 5.0Å range: probe atom residue distance (Å) B Occ D:Br1602 b:139.8 occ:1.00 BR10 D:UOO1602 0.0 139.8 1.0 C09 D:UOO1602 1.9 139.8 1.0 N11 D:UOO1602 2.9 139.8 1.0 N08 D:UOO1602 2.9 139.8 1.0 O14 D:UOO1602 3.1 139.8 1.0 C13 D:UOO1602 3.3 139.8 1.0 C12 D:UOO1602 3.4 139.8 1.0 CG D:PRO1432 3.5 70.8 1.0 CE1 D:TYR1485 3.7 75.0 1.0 CD1 D:TYR1485 4.1 75.0 1.0 C07 D:UOO1602 4.1 139.8 1.0 C06 D:UOO1602 4.1 139.8 1.0 CB D:PRO1432 4.4 70.8 1.0 CZ D:TYR1485 4.5 75.0 1.0 CD D:PRO1432 4.6 70.8 1.0 O37 D:UOO1602 4.7 139.8 1.0 OH D:TYR1485 4.9 75.0 1.0 C15 D:UOO1602 4.9 139.8 1.0

L.Wang, T.-M.Fu. A Unified Mechanism For Human TRPM2 Activation, Desensitization and Inhibition To Be Published.