Bromine in PDB 9dka: Structure of URAT1 in Complex with Benzbromarone

The binding sites of Bromine atom in the Structure of URAT1 in Complex with Benzbromarone (pdb code 9dka). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total 2 binding sites of Bromine where determined in the Structure of URAT1 in Complex with Benzbromarone, PDB code: 9dka:
Jump to Bromine binding site number: 1; 2;

Bromine binding site 1 out of 2 in the Structure of URAT1 in Complex with Benzbromarone


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Structure of URAT1 in Complex with Benzbromarone within 5.0Å range: probe atom residue distance (Å) B Occ A:Br601 b:30.0 occ:1.00 BR1 A:R75601 0.0 30.0 1.0 CAD A:R75601 1.9 30.0 1.0 CAC A:R75601 2.9 30.0 1.0 CAE A:R75601 2.9 30.0 1.0 H2 A:R75601 3.0 30.0 1.0 OAG A:R75601 3.1 30.0 1.0 HZ3 A:LYS393 3.2 63.5 1.0 HZ A:PHE360 3.3 55.4 1.0 HE2 A:PHE364 3.4 69.6 1.0 H13 A:R75601 3.5 30.0 1.0 HA2 A:GLY446 3.6 53.1 1.0 CE2 A:PHE364 3.7 70.4 1.0 HE1 A:PHE241 3.8 73.9 1.0 HZ A:PHE364 3.9 71.7 1.0 CZ A:PHE364 3.9 73.8 1.0 CE1 A:PHE241 4.1 76.6 1.0 NZ A:LYS393 4.1 63.2 1.0 HB2 A:PHE449 4.1 56.5 1.0 HE1 A:PHE360 4.2 56.2 1.0 CZ A:PHE360 4.2 56.9 1.0 CAB A:R75601 4.2 30.0 1.0 CAF A:R75601 4.2 30.0 1.0 HD1 A:PHE241 4.3 68.3 1.0 CD1 A:PHE241 4.3 71.8 1.0 HB3 A:PHE449 4.4 55.1 1.0 CD2 A:PHE364 4.4 68.8 1.0 HZ1 A:LYS393 4.5 61.8 1.0 HE2 A:LYS393 4.5 62.8 1.0 CA A:GLY446 4.5 52.9 1.0 HZ2 A:LYS393 4.5 62.3 1.0 CB A:PHE449 4.6 55.4 1.0 HA3 A:GLY446 4.6 52.9 1.0 CG A:PHE449 4.6 58.9 1.0 CE1 A:PHE360 4.6 58.3 1.0 HD2 A:PHE364 4.6 67.4 1.0 HE3 A:LYS393 4.6 60.9 1.0 HD2 A:PHE449 4.7 61.2 1.0 CD2 A:PHE449 4.7 63.1 1.0 CE A:LYS393 4.7 62.9 1.0 CZ A:PHE241 4.7 75.3 1.0 CAA A:R75601 4.7 30.0 1.0 HE2 A:HIS245 4.8 64.4 1.0 CE1 A:PHE364 4.8 67.7 1.0 HZ A:PHE241 4.9 71.7 1.0

Bromine binding site 2 out of 2 in the Structure of URAT1 in Complex with Benzbromarone


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 2 of Structure of URAT1 in Complex with Benzbromarone within 5.0Å range: probe atom residue distance (Å) B Occ A:Br601 b:30.0 occ:1.00 BR2 A:R75601 0.0 30.0 1.0 CAB A:R75601 1.9 30.0 1.0 CAC A:R75601 2.9 30.0 1.0 CAA A:R75601 2.9 30.0 1.0 H1 A:R75601 3.0 30.0 1.0 OAG A:R75601 3.1 30.0 1.0 H13 A:R75601 3.1 30.0 1.0 HB2 A:PHE241 3.3 62.0 1.0 OD1 A:ASN237 3.6 83.0 1.0 HE2 A:PHE449 3.6 63.6 1.0 HA A:SER238 3.6 63.1 1.0 HD2 A:PHE241 3.8 69.1 1.0 HB3 A:PHE241 3.8 60.9 1.0 CB A:PHE241 3.9 59.9 1.0 CD2 A:PHE241 4.0 75.0 1.0 CG A:PHE241 4.1 66.8 1.0 CE2 A:PHE449 4.1 65.3 1.0 CAD A:R75601 4.2 30.0 1.0 CAF A:R75601 4.2 30.0 1.0 HG22 A:ILE28 4.2 63.8 1.0 HZ A:PHE449 4.3 73.9 1.0 HE3 A:MET214 4.3 58.1 1.0 CZ A:PHE449 4.5 76.1 1.0 CA A:SER238 4.6 63.6 1.0 CG A:ASN237 4.7 75.3 1.0 CAE A:R75601 4.7 30.0 1.0 HD22 A:ASN237 4.7 73.0 1.0 HG23 A:ILE28 4.8 65.1 1.0 CE2 A:PHE241 4.8 78.8 1.0 CG2 A:ILE28 4.8 65.3 1.0 HG21 A:ILE28 4.8 63.5 1.0 CD1 A:PHE241 4.9 71.8 1.0 CD2 A:PHE449 5.0 63.1 1.0

Y.Suo, J.G.Fedor, H.Zhang, K.Tsolova, X.Shi, K.Sharma, S.Kumari, M.Borgnia, P.Zhan, W.Im, S.Y.Lee. Molecular Basis of the Urate Transporter URAT1 Inhibition By Gout Drugs. Nat Commun V. 16 5178 2025.
ISSN: ESSN 2041-1723
PubMed: 40467597
DOI: 10.1038/S41467-025-60480-3