Bromine in PDB 276d: Substitutions at C2' of Daunosamine in the Anticancer Daunorubicin Alter Its Dna-Binding Sequence Specificity

The structure of Substitutions at C2' of Daunosamine in the Anticancer Daunorubicin Alter Its Dna-Binding Sequence Specificity, PDB code: 276d was solved by Y.-G.Gao, W.Priebe, A.H.-J.Wang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	10.00 / 1.80
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	28.090, 28.090, 53.380, 90.00, 90.00, 90.00
R / Rfree (%)	n/a / n/a

The binding sites of Bromine atom in the Substitutions at C2' of Daunosamine in the Anticancer Daunorubicin Alter Its Dna-Binding Sequence Specificity (pdb code 276d). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Substitutions at C2' of Daunosamine in the Anticancer Daunorubicin Alter Its Dna-Binding Sequence Specificity, PDB code: 276d:

Bromine binding site 1 out of 1 in the Substitutions at C2' of Daunosamine in the Anticancer Daunorubicin Alter Its Dna-Binding Sequence Specificity


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Substitutions at C2' of Daunosamine in the Anticancer Daunorubicin Alter Its Dna-Binding Sequence Specificity within 5.0Å range: probe atom residue distance (Å) B Occ A:Br7 b:28.8 occ:1.00 BR A:DM87 0.0 28.8 1.0 C2' A:DM87 1.8 25.7 1.0 C1' A:DM87 2.7 25.1 1.0 C3' A:DM87 3.0 26.2 1.0 O5' A:DM87 3.4 25.3 1.0 C5' A:DG6 3.4 22.5 1.0 N3' A:DM87 3.5 26.0 1.0 C4' A:DM87 3.5 26.0 1.0 O A:HOH9 3.7 31.8 1.0 O A:HOH39 3.9 52.4 1.0 O7 A:DM87 4.0 22.4 1.0 O A:HOH8 4.1 43.8 1.0 C4' A:DG6 4.2 21.9 1.0 C5' A:DM87 4.2 25.8 1.0 C4' A:DC5 4.2 24.4 1.0 O3' A:DC5 4.3 25.4 1.0 O4' A:DC5 4.3 23.8 1.0 O A:HOH41 4.5 53.1 1.0 O5' A:DG6 4.6 24.3 1.0 O4' A:DG6 4.7 21.4 1.0 O2 A:DC5 4.7 20.9 1.0 OP1 A:DG6 4.8 29.9 1.0 O4' A:DM87 4.8 26.3 1.0 C1' A:DC5 4.8 22.9 1.0 O6 A:DM87 4.8 19.0 1.0 C3' A:DC5 5.0 24.2 1.0

Y.G.Gao, W.Priebe, A.H.Wang. Substitutions at C2' of Daunosamine in the Anticancer Drug Daunorubicin Alter Its Dna-Binding Sequence Specificity. Eur.J.Biochem. V. 240 331 1996.
ISSN: ISSN 0014-2956
PubMed: 8841395
DOI: 10.1111/J.1432-1033.1996.0331H.X