Bromine in PDB 2j3s: Crystal Structure of the Human Filamin A Ig Domains 19 to 21

The structure of Crystal Structure of the Human Filamin A Ig Domains 19 to 21, PDB code: 2j3s was solved by T.-R.Kiema, J.Ylanne, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.44 / 2.5
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	72.280, 78.390, 229.040, 90.00, 90.00, 90.00
R / Rfree (%)	25.2 / 29.7

The binding sites of Bromine atom in the Crystal Structure of the Human Filamin A Ig Domains 19 to 21 (pdb code 2j3s). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total 2 binding sites of Bromine where determined in the Crystal Structure of the Human Filamin A Ig Domains 19 to 21, PDB code: 2j3s:
Jump to Bromine binding site number: 1; 2;

Bromine binding site 1 out of 2 in the Crystal Structure of the Human Filamin A Ig Domains 19 to 21


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Crystal Structure of the Human Filamin A Ig Domains 19 to 21 within 5.0Å range: probe atom residue distance (Å) B Occ A:Br3330 b:58.0 occ:1.00 CA A:PHE2259 3.4 31.1 1.0 CA A:GLY2245 3.5 30.9 1.0 O A:GLY2244 3.5 32.3 1.0 O A:HOH2006 3.7 36.1 1.0 OG A:SER2260 3.7 32.8 1.0 C A:PHE2259 3.7 31.8 1.0 NE2 B:GLN2123 3.7 27.7 1.0 N A:PHE2259 3.8 31.4 1.0 N A:SER2260 3.9 32.2 1.0 C A:GLU2258 4.0 32.8 1.0 O A:GLU2258 4.1 33.0 1.0 CD A:PRO2246 4.3 31.6 1.0 CB A:GLU2258 4.3 33.1 1.0 C A:GLY2244 4.3 31.4 1.0 N A:GLY2245 4.3 31.4 1.0 O A:PHE2259 4.3 31.7 1.0 CB A:SER2260 4.5 31.7 1.0 CD B:GLN2123 4.6 28.6 1.0 CB A:PHE2259 4.6 30.8 1.0 ND1 B:HIS2124 4.6 23.1 1.0 OE1 B:GLN2123 4.6 27.8 1.0 CB B:HIS2124 4.6 26.9 1.0 C A:GLY2245 4.7 30.8 1.0 CA A:SER2260 4.8 31.6 1.0 CA A:GLU2258 4.9 33.0 1.0 N A:PRO2246 4.9 31.3 1.0 CG B:HIS2124 5.0 25.7 1.0

Bromine binding site 2 out of 2 in the Crystal Structure of the Human Filamin A Ig Domains 19 to 21


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 2 of Crystal Structure of the Human Filamin A Ig Domains 19 to 21 within 5.0Å range: probe atom residue distance (Å) B Occ B:Br3330 b:86.5 occ:1.00 CG2 B:THR2072 3.3 34.2 1.0 OG1 B:THR2072 3.4 36.1 1.0 CB B:THR2072 3.8 34.6 1.0 CE1 B:PHE2120 3.8 34.6 1.0 O B:GLY2078 3.9 36.7 1.0 CD2 B:LEU2080 4.4 37.1 1.0 CD1 B:PHE2120 4.6 32.7 1.0 CZ B:PHE2120 4.7 33.8 1.0 CB B:LEU2080 4.8 37.2 1.0 CG B:LEU2080 4.9 38.8 1.0 CD1 B:LEU2080 4.9 37.2 1.0 N B:LEU2080 5.0 37.0 1.0

Y.Lad, T.-R.Kiema, P.Jiang, O.T.Pentikanen, C.H.Coles, I.D.Campbell, D.A.Calderwood, J.Ylanne. Structure of Three Tandem Filamin Domains Reveals Auto-Inhibition of Ligand-Binding. Embo J. V. 26 3993 2007.
ISSN: ISSN 0261-4189
PubMed: 17690686
DOI: 10.1038/SJ.EMBOJ.7601827