Bromine in PDB 4a93: Rna Polymerase II Elongation Complex Containing A Cpd Lesion

All present enzymatic activity of Rna Polymerase II Elongation Complex Containing A Cpd Lesion:
2.7.7.6;

The structure of Rna Polymerase II Elongation Complex Containing A Cpd Lesion, PDB code: 4a93 was solved by C.Walmacq, A.C.M.Cheung, M.L.Kireeva, L.Lubkowska, C.Ye, D.Gotte, J.N.Strathern, T.Carell, P.Cramer, M.Kashlev, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	54.09 / 3.40
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	221.637, 391.519, 281.774, 90.00, 90.00, 90.00
R / Rfree (%)	16.5 / 19.9

The structure of Rna Polymerase II Elongation Complex Containing A Cpd Lesion also contains other interesting chemical elements:

Magnesium	(Mg)	1 atom
Zinc	(Zn)	8 atoms

The binding sites of Bromine atom in the Rna Polymerase II Elongation Complex Containing A Cpd Lesion (pdb code 4a93). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Rna Polymerase II Elongation Complex Containing A Cpd Lesion, PDB code: 4a93:

Bromine binding site 1 out of 1 in the Rna Polymerase II Elongation Complex Containing A Cpd Lesion


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Rna Polymerase II Elongation Complex Containing A Cpd Lesion within 5.0Å range: probe atom residue distance (Å) B Occ T:Br22 b:0.6 occ:1.00 BR T:BRU22 0.0 0.6 1.0 C5 T:BRU22 1.9 0.1 1.0 C6 T:BRU22 2.9 0.0 1.0 C4 T:BRU22 2.9 0.9 1.0 O4 T:BRU22 3.1 0.5 1.0 C4 T:DC21 3.6 0.9 1.0 N3 T:DC21 3.8 0.9 1.0 C5 T:DC21 3.9 0.6 1.0 N4 T:DC21 4.0 0.0 1.0 N1 T:BRU22 4.1 0.8 1.0 C2 T:DC21 4.1 0.9 1.0 N3 T:BRU22 4.2 0.5 1.0 C6 T:DC21 4.2 0.7 1.0 N1 T:DC21 4.3 0.6 1.0 C2 T:BRU22 4.6 0.3 1.0 O2 T:DC21 4.8 0.2 1.0 C2' T:DC21 5.0 0.5 1.0

C.Walmacq, A.C.Cheung, M.L.Kireeva, L.Lubkowska, C.Ye, D.Gotte, J.N.Strathern, T.Carell, P.Cramer, M.Kashlev. Mechanism of Translesion Transcription By Rna Polymerase II and Its Role in Cellular Resistance to Dna Damage. Mol.Cell V. 46 18 2012.
ISSN: ISSN 1097-2765
PubMed: 22405652
DOI: 10.1016/J.MOLCEL.2012.02.006