Atomistry » Bromine » PDB 4alv-4d46 » 4bqh
Atomistry »
  Bromine »
    PDB 4alv-4d46 »
      4bqh »

Bromine in PDB 4bqh: Crystal Structure of the Uridine Diphosphate N- Acetylglucosamine Pyrophosphorylase From Trypanosoma Brucei in Complex with Inhibitor

Enzymatic activity of Crystal Structure of the Uridine Diphosphate N- Acetylglucosamine Pyrophosphorylase From Trypanosoma Brucei in Complex with Inhibitor

All present enzymatic activity of Crystal Structure of the Uridine Diphosphate N- Acetylglucosamine Pyrophosphorylase From Trypanosoma Brucei in Complex with Inhibitor:
2.7.7.23;

Protein crystallography data

The structure of Crystal Structure of the Uridine Diphosphate N- Acetylglucosamine Pyrophosphorylase From Trypanosoma Brucei in Complex with Inhibitor, PDB code: 4bqh was solved by W.Fang, O.G.Raimi, D.M.F.Vanaalten, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 40.00 / 1.75
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 59.930, 103.000, 187.140, 90.00, 90.00, 90.00
R / Rfree (%) 18.923 / 22.101

Bromine Binding Sites:

The binding sites of Bromine atom in the Crystal Structure of the Uridine Diphosphate N- Acetylglucosamine Pyrophosphorylase From Trypanosoma Brucei in Complex with Inhibitor (pdb code 4bqh). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total only one binding site of Bromine was determined in the Crystal Structure of the Uridine Diphosphate N- Acetylglucosamine Pyrophosphorylase From Trypanosoma Brucei in Complex with Inhibitor, PDB code: 4bqh:

Bromine binding site 1 out of 1 in 4bqh

Go back to Bromine Binding Sites List in 4bqh
Bromine binding site 1 out of 1 in the Crystal Structure of the Uridine Diphosphate N- Acetylglucosamine Pyrophosphorylase From Trypanosoma Brucei in Complex with Inhibitor


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Crystal Structure of the Uridine Diphosphate N- Acetylglucosamine Pyrophosphorylase From Trypanosoma Brucei in Complex with Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Br1539

b:15.3
occ:1.00
 BRA A:9VU1539 0.0 15.3 1.0
CAE A:9VU1539 1.9 14.0 1.0
CAF A:9VU1539 2.8 14.6 1.0
CAD A:9VU1539 2.9 13.9 1.0
CAJ A:9VU1539 3.1 14.8 1.0
CAI A:9VU1539 3.4 14.0 1.0
CAM A:9VU1539 3.4 13.7 1.0
CB A:MET370 3.5 12.2 1.0
OAL A:9VU1539 3.6 15.8 1.0
CG A:MET370 3.7 12.6 1.0
O A:HOH2231 3.7 12.4 1.0
SD A:MET370 3.7 12.9 1.0
C A:MET370 3.8 11.9 1.0
N A:LYS371 3.8 12.1 1.0
O A:MET370 4.0 12.0 1.0
CAC A:9VU1539 4.1 13.6 1.0
CAA A:9VU1539 4.1 14.3 1.0
O A:ALA367 4.2 12.0 1.0
CB A:ALA239 4.2 12.1 1.0
CA A:MET370 4.2 12.1 1.0
CA A:LYS371 4.2 12.8 1.0
O A:HOH2065 4.2 11.9 1.0
CAO A:9VU1539 4.3 13.4 1.0
CG A:LYS371 4.3 15.8 1.0
N A:ALA239 4.4 11.0 1.0
CA A:ALA239 4.5 11.3 1.0
CAB A:9VU1539 4.6 13.8 1.0
CAV A:9VU1539 4.7 12.8 1.0
CAH A:9VU1539 4.8 14.0 1.0
CB A:PHE238 4.8 11.3 1.0
CE A:MET370 4.8 12.3 1.0
OAP A:9VU1539 4.8 14.8 1.0
CAQ A:9VU1539 4.9 13.2 1.0
CB A:LYS371 4.9 13.9 1.0

Reference:

M.D.Urbaniak, I.T.Collie, W.Fang, T.Aristotelous, S.Eskilsson, O.G.Raimi, J.Harrison, I.Hopkins Navratolova, J.A.Frearson, D.M.F.Van Aalten, M.A.J.Ferguson. A Novel Allosteric Inhibitor of the Uridine Diphosphate N- Acetylglucosamine Pyrophosphorylase From Trypanosoma Brucei. Acs Chem.Biol. V. 8 1981 2013.
ISSN: ISSN 1554-8929
PubMed: 23834437
DOI: 10.1021/CB400411X
Page generated: Sat Dec 12 02:18:21 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy