Bromine in PDB 5l1g: Ampa Subtype Ionotropic Glutamate Receptor GLUA2 in Complex with Gyki- Br

The structure of Ampa Subtype Ionotropic Glutamate Receptor GLUA2 in Complex with Gyki- Br, PDB code: 5l1g was solved by M.V.Yelshanskaya, A.K.Singh, J.M.Sampson, A.I.Sobolevsky, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.91 / 4.51
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	92.790, 110.400, 600.140, 90.00, 90.00, 90.00
R / Rfree (%)	25.7 / 29.5

The binding sites of Bromine atom in the Ampa Subtype Ionotropic Glutamate Receptor GLUA2 in Complex with Gyki- Br (pdb code 5l1g). This binding sites where shown within 5.0 Angstroms radius around Bromine atom.
In total 5 binding sites of Bromine where determined in the Ampa Subtype Ionotropic Glutamate Receptor GLUA2 in Complex with Gyki- Br, PDB code: 5l1g:
Jump to Bromine binding site number: 1; 2; 3; 4; 5;

Bromine binding site 1 out of 5 in the Ampa Subtype Ionotropic Glutamate Receptor GLUA2 in Complex with Gyki- Br


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 1 of Ampa Subtype Ionotropic Glutamate Receptor GLUA2 in Complex with Gyki- Br within 5.0Å range: probe atom residue distance (Å) B Occ A:Br902 b:0.4 occ:1.00 BR1 A:GYB902 0.0 0.4 1.0 CAY A:GYB902 1.9 0.4 1.0 CAV A:GYB902 2.9 0.3 1.0 CAX A:GYB902 2.9 0.1 1.0 NBA A:GYB902 3.2 0.6 1.0 OG D:SER615 3.2 0.7 1.0 CB D:SER615 3.4 0.3 1.0 CD2 A:LEU787 3.6 0.8 1.0 CD2 A:LEU620 3.6 0.5 1.0 CD1 A:LEU787 3.7 0.1 1.0 CA D:SER615 4.0 0.6 1.0 CG A:LEU787 4.2 0.1 1.0 CAW A:GYB902 4.2 0.6 1.0 CAU A:GYB902 4.2 0.3 1.0 CG A:LEU620 4.2 0.5 1.0 CD1 A:LEU620 4.3 0.0 1.0 CD1 A:LEU624 4.4 0.4 1.0 CAT A:GYB902 4.7 0.4 1.0 O D:SER615 4.8 0.7 1.0 C D:SER615 4.9 0.6 1.0

Bromine binding site 2 out of 5 in the Ampa Subtype Ionotropic Glutamate Receptor GLUA2 in Complex with Gyki- Br


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 2 of Ampa Subtype Ionotropic Glutamate Receptor GLUA2 in Complex with Gyki- Br within 5.0Å range: probe atom residue distance (Å) B Occ A:Br903 b:58.0 occ:0.25 BR1 A:GYB903 0.0 58.0 0.2 CAY A:GYB903 1.9 0.4 0.3 OG B:SER614 2.7 0.7 1.0 CAX A:GYB903 2.8 0.2 0.3 CAV A:GYB903 2.8 0.1 0.3 NBA A:GYB903 3.0 0.2 0.3 CB B:SER614 3.7 0.6 1.0 CA B:SER614 3.7 0.9 1.0 O B:ILE613 3.8 0.6 1.0 N B:SER614 4.0 0.3 1.0 OG1 C:THR617 4.0 0.8 1.0 C B:ILE613 4.1 0.8 1.0 CAW A:GYB903 4.1 0.2 0.3 CAU A:GYB903 4.1 0.8 0.3 OG1 B:THR617 4.2 0.7 1.0 CG1 B:ILE613 4.4 0.3 1.0 CG2 C:THR617 4.6 0.6 1.0 CAT A:GYB903 4.6 0.4 0.3 CB B:THR617 4.7 0.5 1.0 CD1 B:ILE613 4.8 0.4 1.0 CB C:THR617 4.9 0.4 1.0 CB B:ILE613 4.9 0.7 1.0

Bromine binding site 3 out of 5 in the Ampa Subtype Ionotropic Glutamate Receptor GLUA2 in Complex with Gyki- Br


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 3 of Ampa Subtype Ionotropic Glutamate Receptor GLUA2 in Complex with Gyki- Br within 5.0Å range: probe atom residue distance (Å) B Occ B:Br902 b:0.5 occ:1.00 BR1 B:GYB902 0.0 0.5 1.0 CAY B:GYB902 1.9 0.6 1.0 CAX B:GYB902 2.9 0.9 1.0 CAV B:GYB902 2.9 0.1 1.0 NBA B:GYB902 3.1 0.8 1.0 CD2 B:LEU620 3.5 0.0 1.0 CG B:LEU620 3.9 0.5 1.0 CB A:SER615 4.0 0.7 1.0 OG A:SER615 4.2 0.0 1.0 CAW B:GYB902 4.2 0.8 1.0 CD1 B:LEU620 4.2 0.5 1.0 CAU B:GYB902 4.2 0.3 1.0 CA A:SER615 4.3 1.0 1.0 CD1 B:LEU624 4.5 0.6 1.0 CD2 B:LEU624 4.5 0.6 1.0 O A:SER615 4.7 0.1 1.0 CAT B:GYB902 4.7 0.6 1.0 ND2 B:ASN791 4.8 0.4 1.0

Bromine binding site 4 out of 5 in the Ampa Subtype Ionotropic Glutamate Receptor GLUA2 in Complex with Gyki- Br


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 4 of Ampa Subtype Ionotropic Glutamate Receptor GLUA2 in Complex with Gyki- Br within 5.0Å range: probe atom residue distance (Å) B Occ C:Br902 b:0.8 occ:1.00 BR1 C:GYB902 0.0 0.8 1.0 CAY C:GYB902 1.9 1.0 1.0 CAV C:GYB902 2.9 0.5 1.0 CAX C:GYB902 2.9 0.6 1.0 NBA C:GYB902 3.2 0.5 1.0 OG B:SER615 3.2 0.6 1.0 CB B:SER615 3.3 0.0 1.0 CD1 C:LEU787 4.1 0.1 1.0 CD2 C:LEU620 4.1 0.4 1.0 CAU C:GYB902 4.2 1.0 1.0 CAW C:GYB902 4.2 1.0 1.0 CA B:SER615 4.3 0.8 1.0 CD2 C:LEU787 4.4 0.9 1.0 O B:SER615 4.6 0.1 1.0 CG C:LEU787 4.7 0.9 1.0 CAT C:GYB902 4.7 0.2 1.0 C B:SER615 4.9 0.1 1.0 CD1 C:LEU620 4.9 0.7 1.0 CG C:LEU620 4.9 0.1 1.0

Bromine binding site 5 out of 5 in the Ampa Subtype Ionotropic Glutamate Receptor GLUA2 in Complex with Gyki- Br


Mono view


Stereo pair view

A full contact list of Bromine with other atoms in the Br binding site number 5 of Ampa Subtype Ionotropic Glutamate Receptor GLUA2 in Complex with Gyki- Br within 5.0Å range: probe atom residue distance (Å) B Occ D:Br902 b:0.2 occ:1.00 BR1 D:GYB902 0.0 0.2 1.0 CAY D:GYB902 1.9 0.3 1.0 CAV D:GYB902 2.9 0.4 1.0 CAX D:GYB902 2.9 0.4 1.0 NBA D:GYB902 3.2 0.1 1.0 CB C:SER615 3.4 0.7 1.0 CA C:SER615 3.6 0.2 1.0 OG C:SER615 3.6 1.0 1.0 O C:SER615 3.7 0.6 1.0 CD1 D:LEU624 4.0 0.9 1.0 C C:SER615 4.1 0.5 1.0 CAW D:GYB902 4.2 0.5 1.0 CAU D:GYB902 4.2 0.8 1.0 CB C:ASN619 4.5 0.5 1.0 CAT D:GYB902 4.7 0.9 1.0 CD1 D:LEU787 4.8 0.8 1.0 N C:ASN619 4.8 0.6 1.0 N C:SER615 4.8 0.6 1.0 CB C:ALA618 5.0 0.8 1.0 O D:LEU620 5.0 0.8 1.0

M.V.Yelshanskaya, A.K.Singh, J.M.Sampson, C.Narangoda, M.Kurnikova, A.I.Sobolevsky. Structural Bases of Noncompetitive Inhibition of Ampa-Subtype Ionotropic Glutamate Receptors By Antiepileptic Drugs. Neuron V. 91 1305 2016.
ISSN: ISSN 0896-6273
PubMed: 27618672
DOI: 10.1016/J.NEURON.2016.08.012